New targeted drug shows promise for Hard-to-Treat leukemia

NCT ID NCT02337829

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested a drug called acalabrutinib in 48 adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had a specific high-risk genetic change (deletion 17p). Some participants had already tried other treatments, while others were newly diagnosed. The goal was to see how well the drug shrank or controlled the cancer by blocking a key protein (BTK) that helps cancer cells grow. Results were measured using standard response criteria.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia chromosome 17p deletion leukemia lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Bethesda, Maryland, 20892, United States