Drug cocktail may save tiniest Babies' hearts and lungs

NCT ID NCT05340582

Recruiting now Disease control Sponsor: Mount Sinai Hospital, Canada Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two medicines (acetaminophen and ibuprofen) together works better than ibuprofen alone to close a common heart blood vessel in extremely premature infants (born before 27 weeks). About 310 babies will take part. The goal is to see if the combo reduces death or severe lung disease, and improves development at 18-30 months.

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Conditions

The condition(s) this trial relates to.

patent ductus arteriosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PATENT DUCTUS ARTERIOSUS AFTER PREMATURE BIRTH

Contacts and locations

Locations

Centre Hospitalier de l'Université Laval
NOT_YET_RECRUITING

Québec, Quebec, G1V 4G2, Canada
John Hunter Hospital
ACTIVE_NOT_RECRUITING

Newcastle, New South Wales, 2300, Australia
McMaster Children's Hospital
RECRUITING

Hamilton, Ontario, L8N 3Z5, Canada
Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
Prince of Wales Hospital
NOT_YET_RECRUITING

Shatin, NT, Hong Kong
Royal Alexandra Hospital
RECRUITING

Edmonton, Ontario, T5H 3V9, Canada
Royal North Shore Hospital
RECRUITING

St Leonards, New South Wales, 2065, Australia
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
The Rotunda Hospital
ACTIVE_NOT_RECRUITING

Dublin, Ireland

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