Could a common painkiller replace ibuprofen for preemie heart treatment?
NCT ID NCT04037514
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether paracetamol works as well as ibuprofen for closing a common heart duct problem in premature infants. 133 babies born at or before 30 weeks were randomly given one of the two drugs. The goal was to see which drug closes the duct more effectively and safely.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
paracetamol and ibuprofen
What this could lead to
If paracetamol works as well as ibuprofen, it could offer a safer option for closing a heart duct in premature babies.
What could go wrong
This is a completed Phase 3 trial with 133 infants, but results may not apply to all preemies. Both drugs have known side effects, and the duct may still reopen.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital Materno-Infantil (Hospital Regional Carlos Haya) Málaga:
Málaga, Málaga, Spain
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Hospital Reina Sofía
Córdoba, Cordoba, Spain
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Hospital Universitari i Politècnic La Fe
Valencia, Valencia, 46026, Spain
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Hospital Universitario de Cabueñes
Gijón, Gijón, Spain