Promising new combo for Hard-to-Treat breast cancer

NCT ID NCT02747004

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 study tests the drug abemaciclib, either alone or with tamoxifen, in 234 women with a specific type of advanced breast cancer (HR+, HER2-). The goal is to see if these treatments can slow cancer growth in patients whose disease has progressed after prior therapies. Participants take the drugs by mouth, and researchers track how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: abemaciclib (a targeted cancer drug) and tamoxifen (a hormone therapy)
What this could lead to: If successful, this could offer a new treatment option for women with advanced breast cancer that has stopped responding to other therapies.
What could go wrong: This is a mid-stage trial with only 234 participants, so results may not apply to everyone. Side effects from the drugs could be significant, and the combination may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CANCER

Contacts and locations

Locations

AKH

Vienna, 1090, Austria
Azienda Ospedaliera Universitaria Federico II

Naples, 80131, Italy
Baskent University Dr. Turgut Noyan Research and Training Center

Adana, 1250, Turkey (Türkiye)
CENIT Centro de Neurociencias, Investigación y Tratamiento

CABA, Buenos Aires, C1125ABD, Argentina
Centre Hospitalier Universitaire Sart Tilman

Liège, 4000, Belgium
Centre Oscar Lambret

Lille, Hauts-de-France, 59020, France
Centro Hemato Oncologico Privado

San Bernardino, Toluca, 50080, Mexico
Centro Para la Atención Integral del Paciente Oncologico (CAIPO)

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Chang Gung Memorial Hospital - Linkou

Taoyuan City, 33305, Taiwan
China Medical University Hospital

Taichung, 40447, Taiwan
Clinica Viedma

Viedma, Río Negro Province, R8500ACE, Argentina
Clinica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária LTDA

São Paulo, 01317-000, Brazil
Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03766, United States
Erciyes University Faculty of Medicine

Kayseri, Melikgazi, 38039, Turkey (Türkiye)
Fakultni Nemocnice v Motole

Prague, 150 06, Czechia
Fakultni Poliklinika VFN

Prague, 128 08, Czechia
Fakultni nemocnice Kralovske Vinohrady

Prague, 100 34, Czechia
Fundacion Ars Medica

San Salvador de Jujuy, Jujuy Province, Y4600APW, Argentina
Fundação Pio XII - Hospital de Câncer de Barretos

Barretos, São Paulo, 14784400, Brazil
Grand Hopital de Charleroi-Site Notre-Dame

Charleroi, 6000, Belgium
Grupo Medico Camino Sc

Mexico City, 03310, Mexico
Hacettepe University Faculty of Medicine

Ankara, 06100, Turkey (Türkiye)
Hospital Clinic I Provincial

Barcelona, 08036, Spain
Hospital Clinico San Carlos

Madrid, 28040, Spain
Hospital Clínico Universitario de Valencia

Valencia, 46010, Spain
Hospital General Universitario Gregorio Marañon

Madrid, 28007, Spain
Hospital São Lucas - PUCRS - ONCOLOGY

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital Universitario 12 de Octubre

Madrid, 28041, Spain
Hospital Universitario Ramón y Cajal

Madrid, Madrid, Comunidad de, 28034, Spain
Icesp - Instituto Do Câncer Do Estado de São Paulo

São Paulo, 01246000, Brazil
Institut Paoli-Calmettes

Marseille, Provence-Alpes-Côte d'Azur Region, 13273, France
Instituto de Oncología de Rosario

Rosario, Santa Fe Province, S2000KZE, Argentina
Kath. Marienkrankenhaus gGmbH

Hamburg, 22087, Germany
Mackay Memorial Hospital

Taipei, 10449, Taiwan
Marmara University Medical Faculty

Istanbul, 34668, Turkey (Türkiye)
Masarykuv onkologicky ustav

Brno, Czech Republic, 656 53, Czechia
Medipol Mega University Hospital

Istanbul, 34214, Turkey (Türkiye)
Medizinische Universitaet Graz

Graz, Styria, 8036, Austria
Neurociencias Estudios Clinicos

Culiacán, Sinaloa, 80020, Mexico
Oaxaca Site Management Organization

Oaxaca City, 68000, Mexico
Ospedale Bellaria - Azienda USL di Bologna

Bologna, 40139, Italy
Ospedale Sacro Cuore Don G. Calabria

Negrar, Verona, 37024, Italy
Polic.Umberto I -Univ. La Sapienza

Roma, Rome, 00161, Italy
Republic Oncology Dispensary of MoH of Republic Tatarstan

Kazan', 420029, Russia
Saint-Petersburg city clinical oncology dispensary

Saint Petersburg, 198255, Russia
Sanatorio Parque

Salta, 4400, Argentina
St-Petersburg scientifical practical center of specialized medical care

Saint Petersburg, 197758, Russia
Taipei Medical University Shuang Ho Hospital

New Taipei City, 235, Taiwan
Taipei Veterans General Hospital

Taipei, 11217, Taiwan
Tennessee Oncology PLLC

Nashville, Tennessee, 37203, United States
The Center for Cancer and Blood Disorders

Fort Worth, Texas, 76104, United States
The University of Arizona Cancer Center

Tucson, Arizona, 85724, United States
Thomayerova nemocnice

Praha 4 - Krc, 140 59, Czechia
Universitair Ziekenhuis Gent

Ghent, Oost-Vlaanderen, 9000, Belgium
University of Wisconsin Clinical Research Center

Madison, Wisconsin, 53705, United States
Universitätsklinik Innsbruck

Innsbruck, Tyrol, 6020, Austria
Universitätsklinikum Ulm

Ulm, Baden-Wurttemberg, 89081, Germany
VITAZ

Sint-Niklaas, Oost-Vlaanderen, 9100, Belgium

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