New drug combo tested for tough cancers

NCT ID NCT05599984

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests an investigational drug called ABBV-706, alone or combined with other drugs, in about 288 adults with advanced solid tumors like small cell lung cancer, high-grade brain tumors, and neuroendocrine cancers. The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. Participants will receive the drug through an IV and will be closely monitored with frequent blood tests and scans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ABBV-706 (an investigational drug) given alone or with budigalimab, carboplatin, or cisplatin

What this could lead to

If it works, this could point toward a new treatment option for people with advanced small cell lung cancer, high-grade brain tumors, or neuroendocrine cancers.

What could go wrong

This is a very early Phase 1 trial, so the drug may not work or could have serious side effects. It is also a small study, so results may not apply to everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

astrocytoma (excluding glioblastoma) atypical carcinoid tumor central nervous system cancer familial medullary thyroid carcinoma glioblastoma large cell neuroendocrine carcinoma neoplasm neuroendocrine carcinoma oligodendroglioma prostate neuroendocrine neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOLID TUMORS

Contacts and locations

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Locations

Austin Health and Ludwig Institute for Cancer Research /ID# 255174

Heidelberg, Victoria, 3084, Australia
Banner MD Anderson Cancer Ctr /ID# 260129

Gilbert, Arizona, 85234, United States
Barbara Ann Karmanos Cancer In /ID# 261799

Detroit, Michigan, 48201, United States
CHA Bundang Medical Center /ID# 248939

Seongnam, Gyeonggido, 13496, South Korea
Cancer Hospital - Chinese Academy Of Medical Sciences /ID# 270044

Beijing, Beijing Municipality, 100021, China
Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin /ID# 259413

Berlin, 12203, Germany
Chonnam National University Hwasun Hospital /ID# 248943

Hwasun-gun, Jeonranamdo, 58128, South Korea
Chris O'Brien Lifehouse /ID# 259087

Camperdown, New South Wales, 2050, Australia
City Of Hope Comprehensive Cancer Center /ID# 271295

Duarte, California, 91030, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 259884

Irvine, California, 92618, United States
Duke Cancer Center /ID# 246285

Durham, North Carolina, 27710, United States
First Affiliated Hospital of China Medical University /ID# 270041

Shenyang, Liaoning, 110001, China
Fondazione IRCCS San Gerardo dei Tintori - Ospedale San Gerardo /ID# 258228

Monza, Monza E Brianza, 20052, Italy
Fort Wayne Medical Oncology and Hematology, Inc /ID# 260130

Fort Wayne, Indiana, 46804, United States
Georgetown University Hospital /ID# 255352

Washington D.C., District of Columbia, 20007, United States
Hadassah Medical Center-Hebrew University /ID# 255147

Jerusalem, 91120, Israel
Henry Ford Hospital /ID# 246648

Detroit, Michigan, 48202, United States
Hokkaido Cancer Center /ID# 261278

Sapporo, Hokkaido, 003-0804, Japan
Hospital Clinico Universitario de Valencia /ID# 257290

Valencia, 46010, Spain
Hospital HM Nou Delfos /ID# 264851

Barcelona, 08023, Spain
Hospital Santa Creu i Sant Pau /ID# 257294

Barcelona, 08041, Spain
Hospital Universitario 12 de Octubre /ID# 258658

Madrid, 28041, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 257295

Madrid, 28040, Spain
Hospital Universitario HM Sanchinarro /ID# 258657

Madrid, 28050, Spain
Hospital Universitario Ramon y Cajal /ID# 257291

Madrid, 28034, Spain
Hospital Universitario Vall de Hebron /ID# 258659

Barcelona, 08035, Spain
Hospital Universitario Virgen del Rocio /ID# 256940

Seville, 41013, Spain
Institut Bergonie /ID# 258655

Bordeaux, Gironde, 33000, France
Institut Gustave Roussy /ID# 260334

Villejuif, Val-de-Marne, 94805, France
Institut Régional du Cancer Montpellier /ID# 265086

Montpellier, 34298, France
Istituto Europeo Di Oncologia /ID# 256804

Milan, Milano, 20141, Italy
Klinikum der Universitaet Muenchen - Campus Innenstadt /ID# 259412

Munich, Bavaria, 80336, Germany
Kyoto University Hospital /ID# 259419

Kyoto, Kyoto, 606-8507, Japan
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 246303

New York, New York, 10065-6007, United States
National Cancer Center /ID# 248938

Goyang-si, Gyeonggido, 10408, South Korea
National Cancer Center Hospital /ID# 259418

Chuo-ku, Tokyo, 104-0045, Japan
National Cancer Center Hospital East /ID# 259417

Kashiwa-shi, Chiba, 277-8577, Japan
National Hospital Organization Shikoku Cancer Center /ID# 261279

Matsuyama, Ehime, 791-0280, Japan
Northwest Medical Specialties - Tacoma /ID# 262801

Tacoma, Washington, 98405, United States
Peter MacCallum Cancer Ctr /ID# 259197

Melbourne, Victoria, 3000, Australia
Rambam Health Care Campus /ID# 255059

Haifa, 3109601, Israel
START Midwest /ID# 251257

Grand Rapids, Michigan, 49546-7062, United States
Samsung Medical Center /ID# 248936

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Seoul National University Hospital /ID# 248940

Seoul, Seoul Teugbyeolsi, 03080, South Korea
Shanghai Chest Hospital /ID# 270036

Shanghai, Shanghai Municipality, 200030, China
Shanghai East Hospital /ID# 268615

Shanghai, Shanghai Municipality, 200120, China
Shanghai Pulmonary Hospital /Id# 270039

Shanghai, Shanghai Municipality, 200433, China
Shizuoka Cancer Center /ID# 261277

Sunto-gun, Shizuoka, 411-8777, Japan
South Texas Accelerated Research Therapeutics /ID# 248946

San Antonio, Texas, 78229, United States
St. Lukes Hosp. of Kansas City /ID# 259958

Kansas City, Missouri, 64111, United States
Tennessee Oncology, PLLC /ID# 246283

Nashville, Tennessee, 37203, United States
The Cancer Institute Hospital Of JFCR /ID# 260132

Koto-ku, Tokyo, 135-8550, Japan
The Chaim Sheba Medical Center /ID# 254915

Ramat Gan, Tel Aviv, 5265601, Israel
The Kinghorn Cancer Centre /ID# 260874

Darlinghurst, New South Wales, 2010, Australia
UH Cleveland Medical Center /ID# 246641

Cleveland, Ohio, 44106, United States
Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 270038

Wuhan, Hubei, 430022, China
Univ Oklahoma HSC /ID# 250884

Oklahoma City, Oklahoma, 73117, United States
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 259414

Dresden, Saxony, 01307, Germany
University of Chicago Medical Center /ID# 256334

Chicago, Illinois, 60637, United States
University of Iowa Hospitals and Clinics /ID# 246638

Iowa City, Iowa, 52242, United States
University of Texas MD Anderson Cancer Center /ID# 246287

Houston, Texas, 77030, United States
University of Utah /ID# 246640

Salt Lake City, Utah, 84112-5500, United States
Wakayama Medical University Hospital /ID# 260131

Wakayama, Wakayama, 641-8510, Japan
Washington University-School of Medicine /ID# 246286

St Louis, Missouri, 63110, United States
Yale New Haven Hospital /ID# 246647

New Haven, Connecticut, 06510, United States
Yonsei University Health System Severance Hospital /ID# 248937

Seoul, 03722, South Korea