Vanderbilt University

This study investigates whether combining the medication lovastatin with intensive reading tutoring can improve reading abilities in children and young adults (ages 8-20) with Neurofibromatosis Type 1 (NF1) who have reading disabilities. Participants first receive either lovastat…

This study looks at whether adding the drug insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food reward. About 240 people will be split into two groups: one on diet only, the other on diet plus d…

This study tests whether a mild electrical current applied to the skin of the ear can help people with Postural Orthostatic Tachycardia Syndrome (POTS). POTS causes a rapid heart rate and symptoms like light-headedness and fatigue when standing. The treatment aims to stimulate th…

This study looks at how the body processes prostaglandins, which are natural chemicals involved in inflammation. Researchers want to see if one prostaglandin (PGD2) can be turned into another substance (11-dehydro-TxB2) through a new, unknown pathway. Ten healthy adults who are n…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study looks at how the body's automatic nervous system controls blood flow in abdominal veins and how that might lead to high blood pressure in people with Multiple System Atrophy (MSA). Researchers will measure vein responses in about 16 participants aged 40-80 who have MSA…

This study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study screens people with suspected Postural Tachycardia Syndrome (POTS) and healthy volunteers to see how their bodies handle sodium and the hormone aldosterone. Participants undergo autonomic function tests and blood volume measurements. The goal is to understand if a high…

This study looks at liver tissue from 45 adults with nonalcoholic fatty liver disease (NAFLD) to identify which fats and proteins are present and how they change as the disease gets worse. Participants are 18–65 years old and scheduled for abdominal or bariatric surgery. The goal…

This study looks at whether a special fraction teaching program helps 4th-grade students, including those with math learning difficulties, improve their fraction skills. About 2,210 students will take part, with some teachers using the program and others teaching normally. The go…

This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have higher levels of certain antibodies. Researchers also want to know if these antibodies are more common in people whose POTS started a…

This study compares how the kidneys handle salt in people with postural orthostatic tachycardia syndrome (POTS) versus healthy volunteers. Researchers give a liter of saline intravenously and measure how much sodium is excreted in urine. The goal is to see if POTS patients have t…

This study interviews and surveys 70 adolescents and adults with sickle cell disease to understand why they sometimes skip their daily medications. Researchers will also ask what kind of text-message reminders patients would find helpful. The goal is to design a better support sy…