University Hospital Southampton Nhs Foundation Trust

This study is testing whether an implantable defibrillator (ICD) helps people with a certain type of heart failure (non-ischemic cardiomyopathy) live longer. About 2,500 participants will be randomly assigned to receive an ICD or not, and their survival will be tracked for up to …

This study looks at whether vaginal fluid can help detect gynaecological cancers early. Researchers will collect samples from 250 women, including those with and without cancer, to compare specific markers. The goal is to develop a non-invasive test that could improve detection a…

This study is testing a new blood test called Avantect to see if it can find pancreatic cancer early in people who were diagnosed with type 2 diabetes in the last 6 months. About 15,000 adults aged 50-84 will give blood samples and fill out anxiety questionnaires over a year. The…

This study investigates whether drinking nitrate-rich beetroot juice twice a day for three days can improve exercise capacity in people with idiopathic pulmonary fibrosis (IPF), a lung scarring disease that limits activity. Researchers will compare the juice to a placebo in a sma…

This study tests a new way to help teenagers with asthma feel more in control of their condition. Teens aged 12-18 will either get a standard doctor visit or a visit where their confidence in managing asthma is assessed and addressed. After three months, researchers will compare …

Heavy menstrual bleeding affects 1 in 3 women, yet there's no simple test to diagnose it. This study will use wearable sensors and MRI scans to measure uterine activity in 100 women with and without heavy periods. The goal is to identify biological differences that could lead to …

This study observes 160 adults with oesophageal cancer to see if an endoscopic ultrasound (EUS) changes their treatment plan after standard scans. Researchers will also interview patients and doctors to understand their views on using EUS. The goal is to learn when this test is m…

This study watches how immunotherapy for advanced cancer changes patients' physical fitness and quality of life. About 67 adults will do fitness tests and fill out questionnaires before starting treatment and again 12 weeks later. Researchers will also track long-term outcomes li…

This study involves interviews with 30 adults in the UK who have primary ciliary dyskinesia (PCD), a rare condition affecting the lungs and other organs. Researchers want to learn about their personal experiences with fertility, pregnancy, and parenthood. The goal is to better un…

This study tests a small, sticky chest sensor called PneumoRator that measures breathing rate continuously. Researchers will put it on 50 adults before major surgery and compare its readings to standard hospital monitors. The goal is to see if the device is accurate and comfortab…

This study tests a live online group class called GoPREPARE that teaches people how to get fitter, eat better, and manage stress before major cancer surgery. Researchers will recruit 24 patients awaiting surgery and randomly assign them to either the class or standard care. The g…

This study looks at 320 people who had a severe heart attack (STEMI) and have blockages in other arteries besides the one that caused the attack. Researchers will use CT scans and blood tests to see which blockages are likely to cause future problems. The goal is to find out if o…