Sir Run Run Shaw Hospital

This trial tests whether active remote management—where a respiratory therapist regularly reviews ventilator data and adjusts settings—can improve quality of life and reduce flare-ups in COPD patients with chronic hypercapnia using home breathing support. Participants are randoml…

This study tests if adding a targeted drug (becotatug vedotin) to standard chemotherapy and immunotherapy helps shrink tumors better than standard treatment alone in people with advanced bile duct cancer that has a specific gene change (EGFR mutation). About 164 adults with this …

This phase 2 trial tests whether giving a combination of chemotherapy (gemcitabine and cisplatin) plus an immunotherapy drug (envafolimab) before surgery can reduce tumor cells in patients with bile duct cancer at high risk of recurrence. About 34 adults aged 18-80 with resectabl…

This study tests two drugs together—pucotenlimab (which helps the immune system fight cancer) and becotatugvedotin (which targets and kills cancer cells)—in people with advanced bile duct cancer that has not responded to prior treatment. The main goal is to see how many patients'…

This study tests whether a combination of three drugs (becotatug vedotin, pucotenlimab, and cisplatin) given before surgery can shrink or eliminate tumors in people with advanced head and neck cancer. About 30 adults aged 18-70 with stage III/IVA disease who have not had prior tr…

This study tests a new way to measure diaphragm activity using ultrasound in patients on a breathing machine (ventilator). The goal is to see if this measurement can help doctors identify when the lungs are not fully emptying and adjust ventilator pressure accordingly. The study …

This study tests whether a non-invasive wristband that stimulates an acupoint, combined with anti-nausea drugs, can prevent nausea and vomiting after laparoscopic gynecologic surgery. About 212 women will be randomly assigned to receive either real or sham stimulation, plus eithe…

This study tests whether cognitive behavioral therapy (CBT) can reduce mobile phone addiction and improve anxiety and sleep in hospitalized mental health patients. About 140 participants will receive either CBT sessions plus standard care, or standard care alone. The main goal is…

This study looks at the best way to treat varicose veins in the legs. It compares doing everything in one procedure versus treating the main vein first and the branch veins later. About 206 people will take part, and researchers will track how many need repeat treatment, costs, a…

This study asks whether routine medical data can predict which survivors of an emergency intensive care unit (EICU) stay will develop post-traumatic stress disorder (PTSD) one month after leaving the hospital. Researchers will follow about 800 adult patients, collecting details f…

This study tests whether a new ultrasound-based index, called the Regional Diaphragmatic Synchrony Index (RDSI), can predict if patients on ventilators will succeed when their breathing tube is removed. Researchers will measure diaphragm movement and thickness in 110 adults durin…

This study looks back at the hospital records of 1,000 patients with a sudden worsening of COPD (called an acute exacerbation). The goal is to see how doctors choose and change breathing support—like oxygen masks, high-flow nasal cannulas, or ventilators—during a hospital stay. N…