Shanghai Pulmonary Hospital, Shanghai, China

This study tests whether adding a special type of radiation (SF-SBRT) to the usual combination of immunotherapy (toripalimab) and chemotherapy helps people with stage II-III non-small cell lung cancer live longer without the cancer coming back. About 200 participants will be rand…

This study tests an oral chemotherapy (paclitaxel) combined with immunotherapy given before surgery in patients aged 70-85 with non-small cell lung cancer. The goal is to see if this approach can shrink tumors enough to improve surgery outcomes and long-term survival. About 75 pa…

This phase 2 trial tests a combination of nab-paclitaxel (a chemotherapy drug) and local radiation therapy for people with extensive-stage small-cell lung cancer whose disease has worsened after initial treatment. The study aims to see if this combo can improve progression-free s…

This study tests whether combining a targeted drug (furmonertinib) with local treatments like ablation or radiation can help control early-stage non-small cell lung cancer in people who cannot or choose not to have surgery. About 45 participants with specific EGFR gene mutations …

This study tests a new drug combination (JSKN016, toripalimab, and carboplatin) given before surgery to people with stage II or III non-small cell lung cancer that can be removed. The goal is to see if the treatment can completely or mostly eliminate the tumor before the operatio…

This study tests whether adding acetohydroxamic acid (AHA) to a short-course antibiotic regimen can safely and effectively treat multidrug-resistant tuberculosis (MDR-TB). About 120 adults with confirmed MDR-TB will receive either AHA or a placebo alongside standard drugs. The go…

This study tests whether the targeted drug ensartinib can help people with ALK-mutated stage III lung cancer that cannot be removed by surgery. After completing standard chemoradiotherapy, 45 participants will receive either ensartinib or a placebo to see if the drug delays cance…

This study compares two types of surgery for people with a specific kind of lung cancer (adenocarcinoma) that is 2-3 cm in size and has a low-to-intermediate grade. One surgery removes just the part of the lung with the tumor (segmentectomy), while the other removes an entire lob…

This study tests whether adding a traditional Chinese herbal formula called Huanjingjian decoction to standard hormone therapy can improve symptoms and quality of life in women with premature ovarian insufficiency (early menopause). About 276 women aged 18-39 will receive either …

This phase 2 trial tests whether the targeted drug bozitinib, combined with standard chemotherapy, can shrink tumors before surgery in people with stage IIA to IIIC non-small cell lung cancer that has a specific MET gene change. About 34 participants will receive the drug combo f…

Shoulder pain is common after keyhole lung surgery. This study tests whether a gentle electrical stimulation at specific body points (TEAS) before surgery can lower that pain. About 216 adults having lung surgery will be randomly assigned to receive TEAS or standard care. Researc…

This study tests a special care plan to help Chinese patients with advanced EGFR-mutated lung cancer who are taking the drug amivantamab. The plan focuses on preventing common side effects like blood clots, skin rashes, and infusion reactions. About 122 adults will join to see if…

This study tests if giving the numbing drug bupivacaine through a chest tube can reduce pain after minimally invasive lung surgery. About 249 adults having video-assisted thoracoscopic surgery will receive either a low or high dose of bupivacaine, or a placebo. The main goal is t…

This study compares a new electromagnetic navigation system to standard CT scans for guiding surgeons to small lung nodules during surgery. About 400 adults with nodules up to 2 cm will be randomly assigned to one method. The goal is to see which approach helps surgeons find and …

This large observational study will enroll 14,300 people aged 40-74 to see if combining a non-contrast CT scan with a blood test that looks for DNA changes can detect lung cancer earlier. The goal is to develop a more accurate screening method. Participants must have a lung cance…