Royal Marsden Nhs Foundation Trust

This early-phase study tests two drugs, palbociclib and avelumab, together for people with a specific type of advanced breast cancer (AR+ triple-negative). The main goals are to find the safest doses and see if the combination can shrink tumors. About 45 participants with advance…

This study tests a digital exercise program designed to help prostate cancer patients on hormone therapy stick with physical activity. Side effects like weight gain, muscle loss, and fatigue are common, and exercise can help, but many patients struggle to keep it up. The trial wi…

This study is for men with intermediate-risk prostate cancer. It compares standard radiation given in two sessions to a lower-dose version, both using advanced MRI-guided technology. The goal is to see if the lower dose causes fewer urinary side effects while still controlling th…

This study looks at tissue and imaging data from 800 people with high-risk soft tissue sarcoma to find ways to personalize chemotherapy. Participants either have surgery alone or chemo before surgery. The goal is to build a tumor atlas and a tool to predict who benefits from chem…

This study follows 400 adults who need a second surgery for head and neck cancer that returned or remained after initial treatment. Researchers will track how long patients stay cancer-free and their quality of life after this salvage surgery. They will also analyze tumor genetic…

This study looks at whether it is possible and acceptable to take multiple tissue samples (biopsies) from different tumor sites over time in people with metastatic breast cancer. The goal is to understand how the cancer changes and becomes resistant to treatment. Researchers will…

This study aims to understand why some head and neck cancers come back or resist treatment after radiation therapy. Researchers will collect blood, saliva, and tumor samples from 20 adults who have had radiation and are now having robotic surgery. The goal is to learn how the can…

This study is for 500 adults with breast cancer who are about to start treatment like chemotherapy or immunotherapy before surgery. Researchers will collect tumor tissue, blood, and sometimes MRI scans and stool samples during treatment. The goal is to learn why some cancers shri…