National Center For Complementary And Integrative Health (nccih)
Clinical trials sponsored by National Center For Complementary And Integrative Health (nccih), explained in plain language.
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Could a ketamine metabolite replace opioids for acute pain?
Symptom relief Not yet recruitingThis Phase 2 trial tests whether a single dose of (2R,6R)-hydroxynorketamine (HNK), a non-addictive ketamine metabolite, can reduce acute pain in 92 healthy adults. Participants receive either HNK or a placebo intravenously and undergo pain tests, brain scans, and safety monitori…
Phase: PHASE2 • Sponsor: National Center for Complementary and Integrative Health (NCCIH) • Aim: Symptom relief
Last updated Jul 02, 2026 01:00 UTC
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New pain test battery could speed up drug development
Knowledge-focused Not yet recruitingThis pilot study will test a new method to see how two pain medicines, naproxen and pregabalin, work in healthy adults. Up to 25 participants will receive each medicine and a placebo in random order. They will undergo several short, controlled pain tests, like a cold water hand b…
Phase: NA • Sponsor: National Center for Complementary and Integrative Health (NCCIH) • Aim: Knowledge-focused
Last updated Jul 02, 2026 01:00 UTC