Merck Sharp & Dohme Llc

This study tests a new vaccine called V540A to see if it is safe and works as well as the current HPV vaccine (V503) in healthy women aged 16 to 26. HPV is a common virus that can cause certain cancers. V540A is designed to protect against the same 9 HPV types as V503, plus addit…

This early-stage study tests MK-1045, an immunotherapy that helps the immune system fight cancer, in people with two types of non-Hodgkin lymphoma (follicular and diffuse large B-cell). About 200 participants whose cancer has returned or not responded to at least two prior treatm…

This study tests whether adding the targeted drug MK-1084 to the immunotherapy durvalumab helps people with a specific type of advanced lung cancer (KRAS G12C mutation) live longer without their cancer growing. About 310 adults who have finished chemotherapy and radiation without…

This early-stage study tests whether a single dose of the experimental drug MK-8527 changes how the body processes methadone. Researchers will measure methadone levels in the blood of 14 healthy adults over 24 hours. The goal is simply to gather safety and interaction data, not t…