Merck Sharp & Dohme Llc

This phase 2 trial tests V540A, an experimental vaccine designed to protect against 9 HPV types already covered by Gardasil 9, plus additional unique types. About 525 healthy women aged 16-26 will receive either V540A or Gardasil 9 to compare safety and immune response. The goal …

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This study tests a drug called ifinatamab deruxtecan (I-DXd) in children with solid tumors that have returned or not responded to treatment. The drug is an antibody-drug conjugate that targets cancer cells directly. The trial aims to check safety and see if tumors shrink in about…

This Phase 2 trial tests an experimental drug called MK-7262, alone or with another drug called enlicitide, in 750 adults with high levels of lipoprotein(a) – a genetic risk factor for heart disease. The study compares these drugs to a placebo to see if they can safely lower both…

This early-stage trial studies how different tablet forms of MK-1403, a drug designed for heart and blood vessel disease, are absorbed and tolerated in healthy adults. Researchers will measure the drug levels in the blood and monitor for any side effects. The results will help de…

This early-stage study looks at whether a single dose of ulonivirine changes how the body processes methadone. Fourteen healthy adults who are already on a stable methadone program will take methadone alone and then with ulonivirine. The goal is to measure drug levels in the bloo…

This early-phase study tests how the experimental drug MK-8527 behaves in the body when taken with food or with other medicines like probenecid and itraconazole. It involves 44 healthy adults and measures drug levels in the blood. The goal is to gather safety and drug-interaction…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…