Merck Sharp & Dohme Llc

This study tests an experimental vaccine called V132 in healthy adults aged 50 and older. The goal is to see how safe it is and how well it triggers an immune response compared to existing pneumococcal vaccines. Participants will receive one of several formulations of V132 or a c…

This phase 2 trial tests V540A, an experimental vaccine designed to protect against 9 HPV types already covered by Gardasil 9, plus additional unique types. About 525 healthy women aged 16-26 will receive either V540A or Gardasil 9 to compare safety and immune response. The goal …

This phase 2 trial tests the safety of belzutifan, a daily oral tablet, in adolescents with rare solid tumors that cannot be surgically removed or have spread. The study includes three tumor types: pheochromocytoma/paraganglioma (PPGL), wild-type gastrointestinal stromal tumors (…

This trial is testing whether a new drug called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer and delay cancer growth compared to standard chemotherapy. The study includes adults with high-grade serous or…

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This early-stage trial is testing different pill versions of an experimental drug called MK-4082, which is being developed as a potential weight-loss treatment. The study will enroll about 48 healthy adults who are overweight or obese to see how well the body absorbs each version…

This trial tests whether an experimental drug called bomedemstat can help people with polycythemia vera (a condition where the body makes too many red blood cells) who did not get better with or could not tolerate the common treatment hydroxyurea. Participants will receive either…

This phase 2 trial tests an experimental biologic called MK-1045 in people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study aims to see if MK-1045 is safe and tolerable, and how many participants respond to treatment. P…

This phase 3 trial tests whether an experimental drug called MK-8748 can treat diabetic macular edema (DME), a condition where fluid builds up in the retina and blurs vision. About 960 adults with DME will receive either MK-8748 or the standard treatment aflibercept via eye injec…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This study tests the safety and tolerability of sotatercept in Japanese children aged 1 to 18 with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs narrow, making the heart work harder. Participants receive sotatercept injections every three wee…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This early-stage trial is testing an investigational drug called MK-1406 in healthy adults. The goal is to compare what happens to the drug in the body when it's given as two injections versus three injections, and to check if it's safe and well-tolerated. Participants will recei…

This study examines how the body processes nemtabrutinib in people with severe kidney impairment compared to healthy volunteers. By measuring drug levels in the blood after a single dose, researchers aim to understand whether kidney function changes how the drug is handled. The r…

This study investigates how a single dose of the drug ulonivirine is processed by the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measure drug levels in the blood over time to see if liver function affects how the drug is brok…

This early-stage trial studies how different tablet forms of MK-1403, a drug designed for heart and blood vessel disease, are absorbed and tolerated in healthy adults. Researchers will measure the drug levels in the blood and monitor for any side effects. The results will help de…

This early-stage study looks at whether a single dose of ulonivirine changes how the body processes methadone. Fourteen healthy adults who are already on a stable methadone program will take methadone alone and then with ulonivirine. The goal is to measure drug levels in the bloo…