Merck Sharp & Dohme Llc

This study is testing a new HPV vaccine called V540A. It aims to protect against more types of the HPV virus than the current standard vaccine, potentially preventing more cancers. Researchers will compare the safety and immune response of the new vaccine to the existing one in 5…

This study is testing whether an investigational drug called tulisokibart can help control psoriatic arthritis symptoms. About 140 adults with active psoriatic arthritis will receive either the drug or a placebo to compare effects. Researchers will measure improvements in joint p…

This study is testing whether adding a new targeted drug (MK-1084) to an existing immunotherapy helps prevent lung cancer from coming back after surgery. It involves 400 people with a specific genetic mutation (KRAS G12C) whose lung cancer was surgically removed. The main goal is…

This study is testing whether an experimental drug called MK-8690 can help adults with moderate-to-severe ulcerative colitis. About 100 participants will receive either the drug or a placebo for 12 weeks to see if it reduces bowel inflammation and symptoms like frequent stools an…

This study is for people with advanced bladder cancer that has continued to grow despite previous treatments. Researchers want to see if a new drug called sacituzumab tirumotecan helps patients live longer compared to standard non-platinum chemotherapy options. About 590 particip…

This study is testing an experimental drug called ifinatamab deruxtecan for people with advanced esophageal cancer that has worsened after one or two prior treatments. The drug is designed to attach to cancer cells and deliver treatment directly to them. The main goal is to see h…

This study aims to learn about the long-term effects of the cancer drug belzutifan. It is for people who are already taking belzutifan in other related trials for advanced solid tumors or cancers linked to a genetic condition called VHL disease. The main goal is to see how long p…

This early-stage study aims to understand how the body absorbs and processes different tablet versions of the experimental drug enlicitide (MK-0616). It will involve 30 healthy adult volunteers who will take the drug so researchers can measure its levels in the blood over time. T…