Hutchmed

This trial tests whether adding two drugs (surufatinib and camrelizumab) to standard chemotherapy helps people with metastatic pancreatic cancer live longer. About 502 adults who have not had prior treatment for their advanced cancer will be randomly assigned to the new combo or …

This early-phase trial is testing an experimental drug called HMPL-A251 in adults with advanced or metastatic solid tumors that have high levels of a protein called HER2. The study aims to find a safe dose and see if the drug can shrink tumors. About 147 participants will receive…

This Phase 3 trial tests whether adding an experimental pill (HMPL-760) to standard chemotherapy (R-GemOx) helps people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). About 240 adults will be randomly assigned to get either the new drug or a placebo, plus chem…

This early-phase trial tests an experimental drug called HMPL-A580 in 186 adults with advanced or metastatic solid tumors that cannot be removed by surgery. The study aims to find a safe dose and check for early signs that the drug shrinks tumors. It is currently recruiting parti…

This study tests an experimental drug called HMPL-453 in people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer, that has a specific genetic change (FGFR2 fusion). The trial aims to see how well the drug shrinks tumors. About 235 adults will take the dru…

This early study tests an experimental oral drug called HMPL-506 in about 132 adults with specific types of leukemia (AML or ALL) that have come back or not responded to treatment. The main goal is to check safety and find the right dose. Researchers will also look for signs that…