New pill plus chemo aims to tackle tough lymphoma

NCT ID NCT07409428

Recruiting now Disease control Sponsor: Hutchmed Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 21, 2026 · Updated 2 times

Summary

This Phase 3 trial tests whether adding an experimental pill (HMPL-760) to standard chemotherapy (R-GemOx) helps people with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). About 240 adults will be randomly assigned to get either the new drug or a placebo, plus chemo. The main goal is to see if the combo delays cancer growth or improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMPL-760 (a targeted cancer drug taken as a pill) plus R-GemOx (rituximab, gemcitabine, oxaliplatin chemotherapy)
What this could lead to: If successful, this could offer a new treatment option for people with aggressive lymphoma that has come back or not responded to prior therapy.
What could go wrong: This is an early Phase 3 trial, so results are not yet known. The drug may not improve outcomes and could cause side effects like those from chemotherapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSED/REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA

Contacts and locations

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Locations

BEIJING TONGREN HOSPITAL, Capital Medical University
RECRUITING

Beijing, China
Baoding NO.1 Central Hospital
RECRUITING

Baoding, China
Beijing GoBroad Hospital
RECRUITING

Beijing, China
Chongqing University Cancer Hospital
RECRUITING

Chongqing, China
Fudan University Shanghai Cancer Center
RECRUITING

Shanghai, Shanghai Municipality, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, China
Guangdong Provincial People's Hospital
NOT_YET_RECRUITING

Guangzhou, China
Harbin Medical University Cancer Hospital
RECRUITING

Harbin, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, China
Hubei Cancer Hospital
RECRUITING

Wuhan, China
Hunan Cancer Hospital
RECRUITING

Changsha, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
RECRUITING

Tianjin, China
Jiangsu Cancer Hospital
RECRUITING

Nanjing, China
Jiangxi Cancer Hospital
RECRUITING

Nanchang, China
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School
NOT_YET_RECRUITING

Nanjing, China
North China University of Science and Technology Affiliated Hospital
RECRUITING

Tangshan, China
People's Hospital of Hunan Province
RECRUITING

Changsha, China
People's Hospital of Xinjiang Uygur Autonomous Region
NOT_YET_RECRUITING

Ürümqi, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, China
Quanzhou First Hospital.Fujian
RECRUITING

Fujian, China
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
RECRUITING

Shanghai, China
Shandong Cancer Hospital & Institute
RECRUITING

Jinan, China
Shanxi Provincial Cancer Hospital
RECRUITING

Taiyuan, China
Shengjing Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, China
Shenzhen people's hospital
NOT_YET_RECRUITING

Shenzhen, China
Sichuan Provincial People's Hospital
RECRUITING

Chengdu, China
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, China
The Affiliated Hospital of Guizhou Medical University
RECRUITING

Guiyang, China
The Affiliated Hospital of Qingdao University
RECRUITING

Qingdao, China
The Affiliated Hospital of Xuzhou Medical University
NOT_YET_RECRUITING

Xuzhou, China
The First Affiliated Hospital of Bengbu Medical College
RECRUITING

Bengbu, China
The First Affiliated Hospital of Chongqing Medical University
NOT_YET_RECRUITING

Chongqing, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, China
The First Affiliated Hospital of Kunming Medical University
NOT_YET_RECRUITING

Kunming, China
The First Affiliated Hospital of WMU
NOT_YET_RECRUITING

Wenzhou, China
The First Affiliated Hospital of Xi'an Jiaotong University
RECRUITING

Xi'an, China
The First Affiliated Hospital of Xiamen University
NOT_YET_RECRUITING

Xiamen, China
The First Affiliated Hospital of Zhengzhou University
RECRUITING

Zhengzhou, China
The First Affiliated Hospital, Zhejiang University
NOT_YET_RECRUITING

Hangzhou, China

Contact Email: •••••@•••••
The First Hospital of Jilin University
RECRUITING

Changchun, China
The Second Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, China
The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hosiptal)
NOT_YET_RECRUITING

Xi'an, China
The Second Xiangya Hospital of Central South University
RECRUITING

Changsha, China
Tianjin Medical University Cancer Institute & Hospital
RECRUITING

Tianjin, China
Tianjin People's Hospital
RECRUITING

Tianjin, China
Tongji Hospital of Tongji University
RECRUITING

Shanghai, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, China
Wuhan Union Hospital of China
RECRUITING

Wuhan, China
Zhejiang Cancer Hospital
RECRUITING

Hangzhou, China
ZhuJiang Hospital of Southern Medical University（The Second Clinical Medical College）
RECRUITING

Guangzhou, China

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