New hope for Hard-to-Treat cancers? early trial of HMPL-A251 begins

NCT ID NCT07228247

Recruiting now Disease control Sponsor: Hutchmed Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This early-phase trial is testing an experimental drug called HMPL-A251 in adults with advanced or metastatic solid tumors that have high levels of a protein called HER2. The study aims to find a safe dose and see if the drug can shrink tumors. About 147 participants will receive the drug by IV infusion until their disease gets worse or side effects become too severe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HMPL-A251 (an experimental antibody drug given by IV infusion)
What this could lead to: If it works, this could point toward a new treatment option for people with advanced HER2-positive solid tumors that have stopped responding to other therapies.
What could go wrong: This is a very early, first-in-human trial with only 147 participants. The drug may not shrink tumors or could cause serious side effects. Success in this small study does not guarantee it will work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SOLID TUMORS, ADULT

Contacts and locations

Locations

BRCR Global
RECRUITING

Plantation, Florida, 33322, United States
Cleveland Clinic Taussig Cancer Center
RECRUITING

Cleveland, Ohio, 44195, United States
Florida Clinical Trials Group LLC (Plantation)
RECRUITING

Plantation, Florida, 33322, United States
Florida Clinical Trials Group LLC (Tamarac)
NOT_YET_RECRUITING

Tamarac, Florida, 33321, United States
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, China
Henan Cancer Hospital
RECRUITING

Zhengzhou, China
Hunan Cancer Hospital
RECRUITING

Changsha, China
Memorial Sloan Kettering Cancer Center
NOT_YET_RECRUITING

New York, New York, 10065, United States
Northwest Medical Specialties, PLLC
NOT_YET_RECRUITING

Tacoma, Washington, 98405, United States
Peking University First Hospital
RECRUITING

Beijing, China
SCRI HealthONE
RECRUITING

Denver, Colorado, 80218, United States
START New Jersey
NOT_YET_RECRUITING

East Brunswick, New Jersey, 08816, United States
Sun Yat-sen University Cancer Center
RECRUITING

Guangzhou, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, China
The First Hospital of China Medical University
NOT_YET_RECRUITING

Shenyang, China

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