Hospital Do Coracao

This pilot study tests a new radiation schedule for glioblastoma, a serious brain cancer. Instead of standard daily treatments over many weeks, patients receive a higher dose each day for fewer total sessions, combined with the chemotherapy drug temozolomide. The study aims to se…

This study will follow 2000 adults hospitalized with acute heart failure in Brazil to learn how they are treated and what happens to them over the next year. Researchers want to see if doctors are using the latest recommended medicines and find out what barriers prevent better ca…

This study will observe 900 adults in intensive care units (ICUs) in low- and middle-income countries to understand how doctors safely remove breathing tubes (weaning). Researchers will track patients for 7 days after extubation to see how often breathing tubes need to be reinser…

This study looks at whether giving patients one extra hour of breathing support from a ventilator, after they pass a breathing test, helps them stay off the machine for good. About 4,000 ICU adults who have been on a ventilator for more than 72 hours will be randomly assigned to …

This study looks at whether giving critically ill patients one more hour of breathing support from a ventilator, after they pass a breathing test, can reduce the chance they need to be put back on the ventilator within a week. About 4,000 adults in intensive care who have been on…