One more hour on the ventilator: could it prevent breathing failure?

NCT ID NCT07324382

Not yet recruiting Knowledge-focused Sponsor: Hospital do Coracao Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving critically ill patients one more hour of breathing support from a ventilator, after they pass a breathing test, can reduce the chance they need to be put back on the ventilator within a week. About 4,000 adults in intensive care who have been on a ventilator for more than 72 hours will be randomly assigned to either immediate removal or one more hour of support. The goal is to find a better way to wean patients off mechanical ventilation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: positive pressure ventilation
What this could lead to: If it works, this could point toward a simple change in ICU practice that reduces the need for re-intubation and improves outcomes for patients on ventilators.
What could go wrong: This is an early-stage trial testing a procedural change, not a new drug. The benefit may be small or absent, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIRWAY EXTUBATION EXTUBATION FAILURE WEANING MECHANICAL VENTILATION

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