One more hour on the ventilator could save lives, new trial hopes to prove

NCT ID NCT07324460

Not yet recruiting Knowledge-focused Sponsor: Hospital do Coracao Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether giving patients one extra hour of breathing support from a ventilator, after they pass a breathing test, helps them stay off the machine for good. About 4,000 ICU adults who have been on a ventilator for more than 72 hours will be randomly assigned to either immediate removal or one more hour of support. The goal is to see if this simple change reduces the chance of needing the ventilator again or dying within a week.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: one-hour positive pressure ventilation
What this could lead to: If it works, this could lead to a simple change in ICU practice that reduces the need for re-intubation and improves patient outcomes.
What could go wrong: This is an early-stage trial with no phase, and the intervention is a minor timing change, so the benefit may be small or not exist. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIRWAY EXTUBATION EXTUBATION FAILURE WEANING MECHANICAL VENTILATION

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