Gruppo Oncologico Del Nord-ovest

This study tests giving a short course of chemotherapy plus immunotherapy before surgery for people with Merkel cell carcinoma that can be removed. The goal is to see if this approach can completely eliminate the cancer in the removed tissue. About 36 adults with stage II or III …

This study is for people with advanced colorectal cancer that has not responded to standard treatments. It compares two sequences of drugs: panitumumab followed by regorafenib, or the reverse order. The goal is to see which sequence helps patients live longer and controls the can…

This study tests a combination of three drugs (trifluridine/tipiracil, capecitabine, and bevacizumab) in people with metastatic colorectal cancer who have not had chemotherapy for their advanced disease and are not healthy enough for intensive treatment. The goal is to find a saf…

This study tests whether people with a specific type of advanced colorectal cancer (BRAF V600E mutation) can benefit from a second round of a targeted drug combination (encorafenib plus cetuximab). Only patients who previously responded well to the same drugs are eligible, and a …

This study is for people with stage II or III colon cancer at high risk of coming back. It tests whether stronger chemotherapy (FOLFOXIRI) and an extra drug (Trifluridine/Tipiracil) can clear cancer DNA from the blood, which may lower the chance of relapse. A separate group with …