Georgetown University

This phase 2 trial tests whether giving chemotherapy plus the immunotherapy drug cemiplimab (Libtayo) before surgery can shrink tumors enough to allow surgical removal in people with stage 3 non-small cell lung cancer that has spread to certain lymph nodes (N3). About 21 particip…

This study is testing whether people with early-stage HPV-positive throat cancer can be treated with radiation alone at a lower dose, instead of the usual full-dose radiation plus chemotherapy. The goal is to see if this gentler approach can keep the cancer from coming back while…

This study is for people with HPV-positive oropharyngeal (throat) cancer who have had surgery. Researchers want to see if giving a lower dose of radiation to a smaller area (just the neck, not the original tumor site) works as well as the standard higher dose. The goal is to redu…

This study tests a chemotherapy drug called CPX-351 (Vyxeos) as a maintenance treatment for adults with acute myeloid leukemia (AML) who are in remission but cannot have a bone marrow transplant. About 24 participants will receive up to 6 cycles of the drug to see what dose is sa…

This study tests whether adding two immunotherapy drugs (durvalumab and tremelimumab) to standard chemotherapy is safe and effective for people with HIV who have advanced non-small cell lung cancer. About 18 participants will receive the treatment, and researchers will monitor si…

This early-phase study tests the safety of combining an experimental drug called NEROFE with a standard chemotherapy, doxorubicin, in people with advanced solid tumors that have a KRAS mutation and express ST2. The trial aims to find the best dose and schedule for the combination…

This study compares two smoking cessation programs for people undergoing lung cancer screening. About 1,188 participants will either receive phone counseling and nicotine replacement from a health system or be referred to a quitline. The goal is to see which approach leads to mor…

This study tests a drug called sacituzumab govitecan in adults with advanced thymoma or thymic carcinoma that has worsened after at least one prior treatment. The main goal is to see how many patients' tumors shrink or disappear. Participants receive the drug intravenously weekly…

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether a drug called azeliragon can reduce heart damage caused by chemotherapy in women with early-stage breast cancer. About 48 participants will receive azeliragon alongside their standard chemo to see if it is safe and helps protect the heart and thinking abi…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced cervical cancer that has stopped responding to initial treatment. The trial enrolls 35 adults whose cancer has spread or cannot be removed by surgery. The goal is…

This large study in Malawi will test whether extra support—like better communication with providers, peer counselors, and earlier clinic hours—helps people at high risk for HIV stay on their prevention medication. It includes both daily pills and a new long-acting injectable. Nea…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests a website designed to help thyroid cancer patients manage symptoms after radioactive iodine (RAI) treatment. About 88 adults who had RAI in the last three years will use either the new website or a standard one for four weeks. Researchers will check if the tool i…

This pilot study is testing whether a web-based insomnia treatment called SHUTi can help Black/African American prostate cancer survivors sleep better. Forty participants will be randomly assigned to either the SHUTi program or an educational website. The study will check if the …

This study investigates whether restricting access to social media apps on smartphones for three months can improve anxiety and depression in adolescents aged 10 to 14. Half of the 500 participants will have no social media apps on their phones, while the other half will use them…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study enrolls 820 Black and Hispanic women aged 45-74 who are due for both breast and colorectal cancer screening. It compares a bundled navigation program covering both cancers to a single-cancer navigation program. The goal is to see if bundled navigation increases screeni…

This study tests whether a special decision aid website helps people with intermediate-risk thyroid cancer make informed choices about radioactive iodine (RAI) treatment. About 408 participants will be randomly assigned to use either the decision aid or a standard information web…

This study tests a decision aid designed to help Black and Latina women at high risk for breast cancer make informed choices about whether to get a breast MRI in addition to their yearly mammogram. Eighty participants will be randomly assigned to receive either standard risk info…