Duke University

This study is for children aged 2 to 17 with juvenile idiopathic arthritis (JIA) whose first treatment (a TNF inhibitor) did not work well enough. It compares three different medications to a second TNF inhibitor to see which works better at reducing disease activity. The goal is…

This study is testing whether a special CT scanner that can be moved around the hospital can safely take pictures of the chest and belly in children. The scanner is already approved for head scans in adults and kids. The goal is to help children who are too sick to be moved to th…

This study tests a new, ultracompact handheld eye scanner to detect early signs of inherited retinal disease in children under 9. Researchers will take images during routine eye exams to see if the device can spot abnormal development. The goal is to enable earlier diagnosis and …

This study looks at whether giving babies an RSV prevention shot at the same time as their regular vaccines is safe. About 524 infants will either get both shots together or on separate days. The main goal is to see if combining them causes more fever.

This study tests a culturally-tailored program offering long-acting injectable PrEP (lenacapavir) to Latine gay, bisexual men, and transgender women. The goal is to see if this community-delivered approach helps more people start and stay on PrEP compared to standard care. About …

This study looks at whether a pre-treatment exercise program can improve arm or leg function and reduce wound problems in people with soft tissue sarcoma. Participants will exercise before receiving radiation therapy and surgery. The study will track wound complications and tumor…

This early study tests a 14-day course of the oral drug zuranolone in 6 stroke survivors with moderate to severe depression. Researchers want to see if the drug is safe, well-tolerated, and improves mood. Participants take 50 mg daily and complete mood questionnaires and blood te…

This study looks at how two different treatments for liver cancer affect patients' quality of life. About 78 adults with liver cancer who cannot have surgery will receive either a radiology-guided treatment or targeted radiation. The main goal is to see if these treatments help p…

This study compares sending informative text messages versus giving traditional paper handouts to people who have had lumbar spine surgery. The goal is to see if text messages can reduce hospital readmissions and emergency room visits within 30 days after surgery. About 224 adult…

This study looks at whether a special teaching tool can help families of children with acute kidney injury (AKI) better understand the condition. Researchers will test parents' knowledge before and after the tool is used. The goal is to improve care and reduce long-term health pr…

This study aims to see if a short questionnaire can accurately estimate a person's fitness level, measured by oxygen use, compared to a standard exercise test. Researchers will enroll 100 adults who are scheduled for surgery and have low fitness scores. The goal is to develop a s…

This study explores whether showing people detailed diet information from their stool samples can encourage healthier eating. About 600 infants, children, and adults will provide stool samples, get their diet data, and then provide another sample to see if their eating habits imp…

This study tests a new 4D microscope-integrated OCT system during eye surgery on 5 adults with corneal, retinal, or other eye diseases. The goal is to see if the system is easy to use, safe, and provides clear images of eye structures. It is an early pilot study focused on gather…

This study aims to find out why some people with sickle cell disease develop severe, disabling pain while others do not. Researchers will track 70 participants aged 15 to 40 over up to 4 years using surveys and pain tests. The goal is to improve pain management and guide future t…

This study looks at how children under 21 with a type of leukemia called ALL process the medicines they already receive as part of their standard care. Researchers will measure drug levels in the blood to learn more about dosing. About 200 children will take part, and no new or e…

This study looks at whether a short, hands-on training program can help advanced practice providers (like physician assistants and nurse practitioners) in the emergency department better use heart ultrasound. About 75 providers will take part in simulation training and then use u…