Arrowhead Pharmaceuticals

This study is testing whether a new injectable drug called plozasiran can safely and effectively lower very high levels of triglycerides (a type of fat) in the blood. About 446 adults with severe hypertriglyceridemia will receive either the drug or a placebo injection every three…

This study is testing an experimental drug called ARO-ANG3 for people with a rare, severe genetic condition that causes extremely high cholesterol from birth. The main goal is to see if the drug is safe and can effectively lower 'bad' cholesterol (LDL-C) over 24 weeks. Participan…

This study aimed to test whether multiple doses of an experimental drug called ARC-AAT could safely reduce the buildup of a harmful protein in the livers of adults with Alpha-1 Antitrypsin Deficiency. Participants would have received seven intravenous injections and undergone two…

This is an early-stage study to test the safety and effects of a new drug called ARO-CFB. It involves healthy volunteers and patients with kidney diseases caused by an overactive part of the immune system, like IgA Nephropathy. The main goal is to see how the body handles the dru…

This study aimed to test whether adding an experimental drug called ARC-520 to standard Hepatitis B medications could better control the virus. It was designed for adults already taking daily antiviral pills. The trial was withdrawn by the sponsor before any patients were enrolle…

This Phase 3 study is testing whether an investigational drug called plozasiran (ARO-APOC3) can safely and effectively lower dangerously high triglyceride levels in adults with familial chylomicronemia syndrome (FCS), a rare genetic disorder. About 75 participants will receive ei…

This large, late-stage study is testing whether a new injectable drug called plozasiran can safely and effectively lower high triglyceride levels in the blood. About 1,456 adults with this condition will receive either the drug or a placebo shot every three months for a year. The…

This study is testing whether a new injectable drug called plozsiran can safely and effectively lower very high levels of triglycerides (a type of fat) in the blood. About 311 adults with severe hypertriglyceridemia will receive either the drug or a placebo injection every three …