Alliance Foundation Trials, Llc.

This study is testing a combination of four drugs (lenalidomide, ixazomib, dexamethasone, and daratumumab) for older adults or those too frail for a stem cell transplant who have newly diagnosed multiple myeloma. The goal is to see if adding more drugs during long-term 'maintenan…

This large international study is testing whether adding a medication called palbociclib to standard hormone therapy is better at preventing breast cancer from coming back after initial treatment. It involved nearly 5,800 people with early-stage, hormone-sensitive breast cancer w…

This large study is testing whether active monitoring (watchful waiting) is as safe and effective as surgery for women with a very early, low-risk form of breast cancer called DCIS. It aims to see if avoiding surgery can prevent unnecessary treatment and side effects like chronic…

This study is testing two different immunotherapy drug combinations, given before and after standard chemoradiation, for people with stage III non-small cell lung cancer that cannot be removed by surgery. The goal is to see which combination is more promising for keeping the canc…

This study is testing whether combining two oral drugs, palbociclib and ibrutinib, can help control mantle cell lymphoma in patients whose cancer has returned or worsened after at least one prior treatment. The main goal is to see how long the combination can keep the cancer from…

This study is testing if adding a drug called palbociclib to the standard treatment helps people with a specific type of advanced breast cancer live longer without their cancer getting worse. It involves 518 adults whose cancer has spread, is HER2-positive, and is also fueled by …

This study aims to find out which of two common prostate cancer medications—enzalutamide or darolutamide—has less impact on memory, concentration, and other thinking skills. About 111 men with advanced prostate cancer will take one of the drugs and complete regular computer-based…