New combo aims to stall advanced lung cancer

NCT ID NCT05798663

Ongoing Disease control Sponsor: Alliance Foundation Trials, LLC. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase II trial tests whether adding the immunotherapy drugs atezolizumab (with or without tiragolumab) to standard chemoradiotherapy can help people with stage III lung cancer that cannot be removed by surgery. About 178 participants will receive the drugs before, during, and after radiation and chemotherapy. The main goal is to see if the combination delays cancer progression or improves survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (Tecentriq) and tiragolumab, given with chemotherapy and radiation
What this could lead to: If successful, this could point toward a more effective treatment regimen for advanced lung cancer that delays disease progression.
What could go wrong: This is an early-phase trial with only 178 participants, so results may not apply to all patients. Adding immunotherapy also carries risks of immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NSCLC

Contacts and locations

Locations

Hematology Oncology Associates of Central New York, P.C.

East Syracuse, New York, 13057, United States
Kaiser Permanente Oakland Medical Center

Oakland, California, 94611, United States
Kaiser Permanente Roseville Medical Center

Roseville, California, 95661, United States
Kaiser Permanente San Francisco Medical Center

San Francisco, California, 94115, United States
Kaiser Permanente Santa Clara Medical Center

Santa Clara, California, 95051, United States
Kaiser Permanente Vallejo Medical Center

Vallejo, California, 94589, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
New Hampshire Oncology - Hematology, PA

Manchester, New Hampshire, 03103, United States
Ohio State University

Columbus, Ohio, 43210, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
University of California San Diego Moores Cancer Center

La Jolla, California, 92037, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States
Washington University Siteman Cancer Center

St Louis, Missouri, 63110, United States

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