New drug cocktail shows promise for tough blood cancer
NCT ID NCT03478514
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II study tests a combination of two drugs, palbociclib and ibrutinib, in 39 patients with mantle cell lymphoma that has been treated before. The goal is to see if the combo can delay cancer progression. Patients take both pills daily in 28-day cycles.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
palbociclib and ibrutinib
What this could lead to
If successful, this combination could offer a new treatment option for patients with mantle cell lymphoma who have already tried other therapies.
What could go wrong
This is a small, early-phase study with only 39 participants, so results may not apply to all patients. Side effects from the drug combination are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope National Medical Center
Duarte, California, 91010, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Medical University of South Carolina - Hollings Cancer Center
Charleston, South Carolina, 29425, United States
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Ohio State University
Columbus, Ohio, 43210, United States
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Roswell Park Comprehensive Cancer Center
Buffalo, New York, 14263, United States
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St. Joseph Mercy Hospital Cancer Care Center
Ypsilanti, Michigan, 48197, United States
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University of Maryland, Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, 21201, United States
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University of North Carolina
Chapel Hill, North Carolina, 27599, United States
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Weill Cornell Medical College
New York, New York, 10065, United States