VULVA CANCER

This study tests a new immunotherapy for people with advanced HPV-related cancers (cervical, throat, anal, and others). Participants receive specially engineered immune cells designed to attack HPV-infected tumor cells, along with chemotherapy and a drug to boost cell activity. T…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control or shrink advanced solid tumors like lung, pancreas, and colorectal cancers. The study involves 54 adults who…

This study is testing whether two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced vulvar cancer that cannot be removed by surgery. About 80 participants will receive the combination therapy. The main goals are to see how many patients respond to tre…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancers. Ten participants will receive brachytherapy using a personalized 3D-printed mold d…

This study looks at whether regular patient questionnaires and a special blood test (circulating tumor DNA) can detect vulva cancer recurrence earlier than standard follow-up. About 295 women with vulva cancer will be followed for two years, and their results will be compared to …

This study is gathering tumor, blood, and plasma samples from over 1,000 people with certain cancers (ovarian, triple-negative breast, head and neck, cervical, vulva, and sarcoma). The goal is to find new biomarkers that link a tumor's genetic changes and the body's immune respon…