VULVA CANCER

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This Phase 2 trial is testing whether two drugs, pembrolizumab and lenvatinib, can shrink or control vulvar cancer that cannot be surgically removed. About 80 participants will receive the combination in 21-day cycles. The study will measure tumor response and track side effects.

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study is testing whether regular patient surveys and a special blood test (circulating tumor DNA) can spot vulva cancer returning earlier than standard check-ups. About 295 women with vulva cancer will fill out symptom surveys every four months and give blood samples for two…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study collects tumor and blood samples from over 1,000 people with certain cancers (ovarian, breast, head and neck, cervical, vulva, and sarcoma). Researchers will analyze the samples to find links between genetic changes, the immune system, and how the cancer behaves. Parti…