VENOUS LEG ULCER

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study tests whether adding special wound dressings (called CAMPs) to standard care helps close hard-to-heal diabetic foot and leg ulcers better than standard care alone. About 350 adults with these ulcers will be randomly assigned to receive either the extra dressings or usu…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This phase 3 trial tests a donor stem cell treatment called Allo-APZ2-CVU for people with chronic venous leg ulcers that haven't healed with standard therapy. About 250 adults with ulcers between 1 and 25 cm² will receive either the cell therapy or a placebo applied directly to t…

This small study is testing Corplex P, a device made from donated human umbilical cord tissue, to see if it helps heal wounds that won't close on their own, like diabetic foot ulcers. Ten people will receive the device as part of their standard wound care. Researchers will track …

This study was designed to test the safety and performance of the Avelle negative pressure wound therapy system on chronic wounds, including diabetic foot ulcers and venous leg ulcers. The device uses gentle suction to help wounds heal. However, the study was withdrawn before enr…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…