UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Clinical trials for UNDIFFERENTIATED PLEOMORPHIC SARCOMA explained in plain language.
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Virus plus radiation may shrink sarcomas before surgery
Disease control OngoingThis study tests whether a cancer-killing virus (T-VEC) combined with radiation can shrink soft tissue sarcomas before surgery. About 40 adults with newly diagnosed, removable sarcomas will receive the virus injected into the tumor plus radiation. The main goals are to see how ma…
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Experimental combo aims to boost immune attack on sarcoma before surgery
Disease control OngoingThis early-phase study tests the safety of combining two immunotherapy drugs—nivolumab and BO-112—given before surgery for soft tissue sarcoma that can be removed. About 14 adults with certain sarcoma types will receive these drugs to see if they help the immune system fight the …
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE1 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Immunotherapy combo shows promise against rare sarcomas before surgery
Disease control OngoingThis study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) and radiation before surgery can help shrink tumors in people with two rare types of sarcoma. About 32 adults with these cancers that can be surgically removed will receive the treatment an…
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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Virus and radiation combo takes aim at tough sarcomas
Disease control OngoingThis phase 2 trial tests whether injecting a modified herpes virus (TVEC) directly into tumors, combined with radiation therapy before surgery, can shrink advanced soft tissue sarcomas. The study enrolled 2 adults with specific sarcoma types that could not be removed with clear m…
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE2 • Sponsor: John Rieth • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Cancer-Killing virus paired with immunotherapy shows promise in sarcoma trial
Disease control OngoingThis phase 2 study tests a combination of two drugs—talimogene laherparepvec (T-VEC), a virus that attacks cancer cells, and pembrolizumab, an immunotherapy that helps the immune system fight cancer—in 41 adults with advanced sarcoma that has spread or cannot be removed by surger…
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Promising sarcoma combo study pulled before starting
Knowledge-focused TerminatedThis study was designed for adults with certain types of soft tissue sarcoma that have specific immune cell clusters (TLS) in their tumors. Participants would have received pembrolizumab (immunotherapy) with or without olaparib (a DNA repair blocker) before surgery, followed by m…
Matched conditions: UNDIFFERENTIATED PLEOMORPHIC SARCOMA
Phase: PHASE2 • Sponsor: Gustave Roussy, Cancer Campus, Grand Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC