TYPE 2 DIABETES (T2DM)

This Phase 3 trial will test a new once-daily insulin, GZR33, against the standard insulin degludec (Tresiba) in 350 adults with type 2 diabetes whose blood sugar is not well controlled by oral medications. The main goal is to see how well GZR33 lowers blood sugar over 26 weeks c…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This study tests whether personalized marketing messages and discounts can encourage people with prediabetes or type 2 diabetes to switch from refined grains to whole grains when shopping for groceries online. About 216 adults aged 45-70 from the Philadelphia area who already sho…

This Phase 3 study tests whether a daily pill combining obicetrapib and ezetimibe, or obicetrapib alone, can lower LDL (bad) cholesterol more than placebo in 300 people with type 2 diabetes or metabolic syndrome. Participants continue their standard cholesterol medications. The m…

This phase 3 trial compares a new injectable drug, BGM0504, to the established drug semaglutide (Ozempic) in 477 adults with type 2 diabetes. All participants also take metformin. The study measures how well each drug controls blood sugar and weight over 24 weeks. The goal is to …

This study looks at whether sulfasalazine, a drug for inflammatory arthritis, makes the standard diabetes blood test (HbA1c) falsely low. That could mean diabetes goes undiagnosed or is undertreated in these patients. Researchers will use continuous glucose monitors and fasting b…

This study tests whether cinematic virtual reality (VR) is more effective than traditional lectures for teaching medical students about geriatric care. One hundred students at Ohio University will be randomly assigned to either VR training or a lecture. The VR group will experien…

This study will follow 1,000 adults in Hong Kong who have both type 2 diabetes and a common fatty liver condition called MASLD. Researchers will collect health data and blood samples over time to see how the liver disease progresses and to find early markers of serious liver scar…

This study looks at how the hormone glucagon works in people with type 2 diabetes, with or without fatty liver disease. Researchers will give participants low and high doses of glucagon and use scans and blood tests to measure how the liver and heart respond. The goal is to under…

This study looks at whether sexual activity raises the risk of low blood sugar (hypoglycemia) in adults with type 1 or type 2 diabetes who use insulin and continuous glucose monitors. Researchers will track 100 participants for 3 months, comparing glucose levels on days with and …

This study will check how common a condition called hypercortisolism (too much of the stress hormone cortisol) is in people with type 2 diabetes that is hard to control despite standard treatments. Researchers will also see if cortisol levels in saliva are linked to blood sugar c…