TIC DISORDERS

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This trial tests whether a therapy that blends Exposure and Response Prevention (ERP) with Habit Reversal Training (HbRT) can reduce both obsessive-compulsive and tic symptoms in adults with Tourettic OCD — a subtype where OCD and tic disorders overlap. Standard treatments usuall…

This trial tests whether sertraline, a widely used antidepressant, can reduce anxiety in children and teens aged 8 to 17 with neurodevelopmental disorders such as autism, ADHD, Fragile X syndrome, and Tourette syndrome. Participants receive either sertraline or a placebo for seve…

This study tests whether a mindfulness-based program can help adults with Tourette syndrome or persistent tic disorders reduce their tics. Participants will either learn mindfulness techniques to manage urges or receive standard relaxation and coping support. The goal is to see w…

This study is testing a behavioral treatment called CBIT (Comprehensive Behavioral Intervention for Tics) in 200 youth who have tic disorders, such as Tourette's, along with related emotional problems like anxiety or depression. The goal is to see if CBIT can reduce tic severity …

This study tests a personalized, non-invasive brain stimulation technique (TMS) in 60 children aged 5-18 with tic disorders. The goal is to reduce tic severity and understand how the brain changes with treatment. Children also receive behavioral guidance, such as avoiding trigger…

This study tracks how tic symptoms change in 30 youth aged 12-17 with Tourette syndrome or chronic tic disorders. Participants receive 8 sessions of behavioral therapy (CBIT) and complete daily surveys, wear a device to track physiology, and perform weekly tasks. The goal is to i…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This registry will enroll 450 adults with tic disorders to study how tic severity relates to quality of life, and whether this relationship differs between men and women. Participants will complete questionnaires about tics, mood, and daily functioning. The goal is to better unde…