TBI (TRAUMATIC BRAIN INJURY)

This study tests whether giving a concentrated salt solution (hypertonic saline) early after a severe traumatic brain injury can help more people survive and regain independence in daily activities. About 760 adults in intensive care will receive either the salt solution or a sta…

This study tests a program designed to help refugees and asylum seekers who have had a traumatic brain injury (TBI) and struggle with thinking and memory. Researchers want to see if the program is practical and helpful. About 50 people will be split into two groups: one starts th…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests whether cognitive remediation—a type of brain training with exercises and coaching—can improve thinking skills, daily function, and behavior in people staying in a forensic mental health unit. About 30 adults with conditions like psychosis, ADHD, or substance use…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study is testing whether a special electrode placed deep in the brain can detect harmful electrical waves called cortical spreading depolarizations (CSDs) after a traumatic brain injury (TBI). These waves are thought to cause further damage, but they are hard to detect with …

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.