SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

This study is testing whether a single-dose dengue vaccine is safe and works well for people with autoimmune diseases like rheumatoid arthritis or lupus. Researchers will compare about 320 patients with these conditions to 160 healthy volunteers, all living in areas where dengue …

This early-stage study is testing a new cell therapy called YTS109 in children with severe autoimmune diseases that have not improved with standard treatments. About 12 children, aged 5 to 18, will receive a single infusion of these specially engineered cells, which are designed …

This is an early-stage study to check the safety and side effects of a new injection called HC022 in people with lupus. Researchers will give different doses to 32 adult volunteers with lupus to see how their bodies handle the drug and to look for any problems. The main goal is t…

This study aims to see if a new oral medication called enpatoran is effective and safe for treating active skin rashes caused by lupus. It will involve about 202 adults with cutaneous lupus, who may or may not also have systemic lupus. Participants will take either the study drug…

This study is testing whether a new injectable drug called SG301 can help control the symptoms and disease activity of systemic lupus erythematosus (SLE). It will involve about 120 adults with moderate-to-severe lupus who haven't responded well to standard treatments. Participant…

This early-stage study is testing a new type of cell therapy called ICG318 for people with severe, hard-to-treat systemic lupus erythematosus (SLE), including lupus affecting the kidneys. The therapy involves modifying a patient's own immune cells (CAR-T cells) to target and remo…

This study aims to understand how lupus develops in the first years after diagnosis by following 700 newly diagnosed patients across Europe for five years. Researchers will collect health information and biological samples to learn which patients achieve remission and what factor…

This study aims to understand if two specific substances in the blood (MicroRNA-101-3p and Autotaxin) are linked to lupus disease activity. Researchers will compare blood samples from 40 adults with lupus to 40 healthy adults. The goal is to find potential markers that could help…

This study aims to understand how lupus that starts with unusual symptoms differs from more common forms of the disease. Researchers will compare 400 patients with typical and atypical lupus presentations to see if one group has more severe disease activity or accumulates more pe…