STAGE III RECTAL CANCER AJCC V8

This early-stage study aims to find the safest dose of the chemotherapy drug TAS-102 when given alongside radiation therapy to patients with stage II or III rectal cancer. The goal is to shrink the tumor before the patient undergoes standard surgery and follow-up chemotherapy. Re…

This early-stage trial is testing whether combining existing cancer drugs with a new experimental drug (LY3214996) can help control advanced colorectal cancer that has stopped responding to standard treatments. The study aims to find safe doses and see if these combinations can s…

This study is testing a new two-drug combination for people with advanced colorectal cancer that has spread and is no longer responding to standard chemotherapy. The trial combines an experimental pill called SX-682, which aims to block tumor growth, with an existing immunotherap…

This study is testing a new treatment approach for people with locally advanced rectal cancer that has a specific genetic marker (MSI-H/dMMR). The goal is to see if giving two immunotherapy drugs (nivolumab and ipilimumab) along with a short, intense course of radiation before su…

This trial is testing whether a three-drug chemotherapy combination (FOLFIRINOX) works better than the standard two-drug combinations (FOLFOX or CAPOX) for patients with locally advanced rectal cancer. All patients first receive radiation with chemo, then are randomly assigned to…

This study is for people with advanced colorectal cancer that has spread or cannot be removed by surgery and has a specific BRAF gene mutation. It tests if adding the immunotherapy drug nivolumab to two standard targeted drugs works better to control the cancer and stop it from g…

This study aims to understand how rectal cancer surgery affects patients' quality of life over time. Researchers will follow 430 patients for up to 5 years after their surgery, asking them to complete questionnaires about their daily experiences. The goal is to gather information…

This study aims to understand how cancer treatment affects patients' finances and employment. Researchers are following 565 people with early-stage colon or rectal cancer for two years, asking them to complete surveys about costs, work life, and quality of life. The goal is to me…

This study aims to learn if tiny pieces of cancer floating in the blood can help doctors understand how rectal cancer responds to treatment. Researchers are collecting blood samples from 341 patients with rectal cancer and some healthy volunteers to track these 'circulating tumor…