STAGE III RECTAL CANCER AJCC V8

This study tests a drug called zanidatamab given before surgery for people with HER2-positive colorectal cancer that has not spread widely. The goal is to see if the drug can shrink tumors and improve outcomes. About 38 adults will take part, and the study is currently recruiting…

This study is testing whether people with stage II or III rectal cancer can safely avoid surgery by using chemotherapy followed by close monitoring (active surveillance) instead of immediate surgery. The goal is to see if the organ can be preserved without the cancer coming back.…

This early-phase study tests whether a short course of radiation followed by chemotherapy can shrink tumors enough to avoid surgery in people with stage II-III rectal cancer. The goal is to preserve the rectum and improve quality of life. About 25 adults with locally advanced rec…

This early study tests a special PET scan that uses a radioactive tracer (64Cu-M5A) to highlight rectal cancer cells. The goal is to see if this scan can show tumor extent and response better than standard scans in 15 adults with locally advanced rectal cancer before and after ch…

This study looks at whether a simple blood test can help doctors decide if rectal cancer patients can avoid surgery and keep their rectum. Researchers will measure tiny bits of tumor DNA in the blood (ctDNA) before, during, and after standard treatment in 50 adults with stage II …

This study follows 430 people with stage I-IV rectal cancer to see how surgery affects their daily life and well-being. Participants fill out questionnaires about their health and preferences. No new treatments are given—the goal is simply to learn more about what life is like af…

This study is creating and testing a mobile health app to help colorectal cancer survivors and their family caregivers follow healthy lifestyle recommendations. The goal is to see if the app is easy to use and helpful. About 70 people who have finished treatment for stage I-III c…