STAGE II BREAST CANCER

This trial tests whether radiation therapy alone can control breast cancer that has spread to nearby lymph nodes as well as surgery to remove those nodes. Women with stage II or III breast cancer who still have cancer in their sentinel lymph node after chemotherapy are randomly a…

This study tests whether platinum-based chemotherapy (cisplatin or carboplatin) works better than capecitabine in people with a certain type of triple-negative breast cancer that remains after initial chemotherapy and surgery. About 415 participants with stage II-III breast cance…

This study tests whether giving two immunotherapy drugs (decitabine and pembrolizumab) before standard chemotherapy can help the immune system attack HER2-negative breast cancer more effectively. About 46 adults with locally advanced disease will receive a short course of these d…

This phase 3 trial tests whether giving fulvestrant alone or with anastrozole before surgery works better than anastrozole alone for postmenopausal women with estrogen receptor-positive breast cancer. Over 1,400 participants will receive one of these hormone therapies for several…

This study tests two drugs, niraparib and dostarlimab, given before surgery to people with BRCA- or PALB2-mutated breast cancer. The goal is to see if this combination boosts the immune system's attack on the tumor and leads to a complete response (no cancer left at surgery). Abo…

This study tests whether giving two targeted drugs, T-DM1 and pertuzumab, before surgery can completely eliminate early-stage HER2-positive breast cancer. About 164 participants with stage II or III disease will receive the drugs for 18 weeks, then undergo surgery. The main goal …

This phase III trial tests whether a shorter course of radiation (hypofractionated) after mastectomy can prevent cancer recurrence with fewer side effects than standard radiation. About 900 patients with stage II-IIIa breast cancer are participating. The study compares complicati…

This phase 2 trial tests whether a newer drug, margetuximab, combined with chemotherapy, works better than the standard trastuzumab combination for HER2-positive breast cancer before surgery. The study includes 174 people with stage II or III disease who have a specific genetic v…

This study explores whether aerobic exercise, like walking, can lower levels of ctDNA (a marker of cancer in the blood) and help prevent breast, prostate, or colorectal cancer from coming back. Researchers will test different amounts of weekly exercise (90 to 375 minutes) in 33 p…

This phase 2 study tests whether acupuncture can improve memory, focus, and thinking problems (often called 'chemo brain') in people who have had breast, colorectal, prostate, or gynecological cancer. About 48 participants will receive either real acupuncture or sham (fake) acupu…