STAGE I BREAST CANCER AJCC V7

This early-phase trial tests an endoxifen gel applied to the breast in 32 women scheduled for mastectomy. The goal is to find the safest dose and check for skin reactions. Endoxifen may help control or lower breast cancer risk, but this study focuses on side effects and drug leve…

This study tests a new radiation approach for women with early-stage breast cancer. Instead of treating the whole breast, it targets only the area where the cancer was removed, using higher daily doses over a shorter time. The goal is to see if this method causes fewer side effec…

This study tests whether adding the immunotherapy drug pembrolizumab after standard chemotherapy helps prevent breast cancer from returning in people with triple-negative breast cancer. About 1,155 participants who still had cancer after chemo will receive either pembrolizumab or…

This study looks at whether a type of acupuncture that uses mild electrical pulses can help reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women who have had pain for at least 3 months after surgery will be randomly assigned to r…

This study compares a 3-week radiation schedule to the standard 5-week schedule for women with invasive breast cancer who need radiation to the lymph nodes near the breast. The goal is to see if the shorter treatment works just as well to prevent cancer from coming back, while al…

This study tests a precise type of radiation (proton beam) for women with early-stage breast cancer (stage 0 to II). The goal is to see if it keeps the breast looking good and causes fewer side effects than standard radiation. About 200 women will receive the treatment and be fol…