SPASTICITY

This study tests a new drug called IPN10200 for adults with arm muscle stiffness (spasticity) after a stroke or traumatic brain injury. The goal is to find the safest and most effective dose to reduce stiffness and improve movement. About 240 participants will receive either the …

This study explores whether a mild, non-invasive electrical stimulation on the back can reduce spasticity (muscle stiffness) in children with cerebral palsy. About 30 children aged 5 to 17 will do movement exercises and receive gentle stimulation that feels like a tap. Researcher…

This study tests a non-invasive treatment called focused shockwave therapy for arm and hand spasticity in people with spinal cord injury. Spasticity causes involuntary muscle tightness that can limit movement and daily activities. Twelve participants will receive the treatment on…

This study tests whether a full-body stimulation suit used at home can reduce spasticity (muscle stiffness) and ataxia (poor coordination) in people with Multiple Sclerosis. 70 participants will either use the suit daily for 6 weeks or receive usual care only. The goal is to see …

This study tests if freezing specific shoulder nerves (cryoneurolysis) can reduce pain and improve movement in people with spasticity from stroke, multiple sclerosis, or brain injury. About 50 adults will receive either one nerve-freezing session or standard Botox injections, the…

This study is testing a portable, wearable exoskeleton that helps stretch the legs and improve walking in people with spasticity caused by spinal cord injury. Ten veterans will wear the device during stretching, treadmill, and overground walking exercises. The goal is to see if t…

This pilot study will follow 12 first-time stroke patients who develop a stiff, turned-in foot (equinovarus). Researchers will use 3D ultrasound and special movement tests to measure changes in muscles, tendons, and nerves after a standard Botox injection. The goal is not to test…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at how muscle stiffness (spasticity) patterns in the arms and legs of people with multiple sclerosis relate to their quality of life. Researchers will classify these patterns and measure their impact using patient surveys and physical tests. The goal is to better…