SINGLE-VENTRICLE
Clinical trials for SINGLE-VENTRICLE explained in plain language.
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Can a common diuretic protect the liver and heart in children born with one heart chamber?
Disease control CompletedThis trial investigates how the Fontan surgery, which reroutes blood flow in children born with a single heart ventricle, affects the liver and heart. Researchers use MRI scans and blood tests to measure fibrosis (scarring) and lymphatic congestion. They also test whether spirono…
Matched conditions: SINGLE-VENTRICLE
Phase: PHASE1, PHASE2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Home workouts boost fitness in kids with single ventricle hearts
Symptom relief CompletedThis study tested whether a live-video-supervised exercise program could improve fitness in children and teens (ages 8-19) born with a single ventricle, a condition often treated with the Fontan procedure. Participants exercised three times a week for three months, then a mainten…
Matched conditions: SINGLE-VENTRICLE
Phase: NA • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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Researchers study digoxin dosing in infants with rare heart condition
Knowledge-focused CompletedThis study looks at how the heart medication digoxin is processed in infants born with single ventricle heart disease. Researchers will collect blood samples during routine care to measure drug levels. The goal is to better understand dosing, but the study does not change the inf…
Matched conditions: SINGLE-VENTRICLE
Phase: PHASE1, PHASE2 • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Aug 16, 2026 00:00 UTC