RETINAL DEGENERATION

This study tests whether metformin, a pill used for diabetes, can safely slow vision loss in people with ABCA4 retinopathy (including Stargardt disease). About 55 participants aged 12 and older will take metformin daily for 24 months. Researchers will measure changes in the retin…

This study looks at whether the drug ofatumumab can slow down thinning of the retina (the light-sensitive layer at the back of the eye) in people with relapsing-remitting multiple sclerosis (MS). Researchers will follow 75 adults with MS who are either starting or already taking …

This study tests an experimental drug called VP-001 for people with a rare inherited eye disease that causes vision loss. The drug is injected into the eye to see if it is safe and can slow down damage to the retina. About 17 adults who have already received VP-001 in earlier stu…

This study follows 44 people with a rare genetic eye condition caused by PCDH15 mutations to see how their vision changes over 4 years. Researchers measure things like visual field, sharpness, and retinal structure. The goal is not to treat the disease but to learn how it progres…

This study follows 68 people with ABCA4 gene mutations (linked to Stargardt disease and other retinal degenerations) for up to 10 years. Researchers collect blood and skin samples and perform detailed eye exams to track how the disease changes over time. No treatment is given; th…