RETINAL DEGENERATION

This study is testing a new treatment called OpCT-001 for adults with inherited eye diseases that cause blindness, such as retinitis pigmentosa. The treatment involves injecting lab-grown light-sensitive eye cells into the back of the eye. The main goals are to see if the treatme…

This study is testing whether dapagliflozin, a medication typically used for diabetes, can slow the progression of geographic atrophy, an advanced stage of age-related macular degeneration that causes vision loss. About 70 participants with this specific eye condition will take e…

This study is testing if the oral diabetes medication metformin is safe and can slow down the progression of ABCA4 retinopathy, a genetic eye disease that causes vision loss. It will involve about 56 participants aged 12 and older who have the disease. Participants will take metf…

This study is testing the safety and effectiveness of repeat injections of an experimental drug, VP-001, into the eye. It is for adults with a rare, inherited form of vision loss called PRPF31 mutation-associated retinal dystrophy. The goal is to see if the injections can help co…

This study aims to understand and eventually find treatments for serious eye diseases that can lead to blindness, like macular degeneration. Researchers will collect simple samples like hair, skin, or blood from people with these conditions and from healthy volunteers. In the lab…

This study aims to test new, high-tech eye imaging systems that can see microscopic details of the eye, like individual cells and blood flow, which are not visible with standard equipment. Researchers will enroll 1,200 participants, including people with various eye conditions an…

This study aims to understand how retinal diseases affect vision, especially in low light. Researchers will measure how well 500 participants, including healthy people and those with conditions like retinitis pigmentosa, can see in the dark. The goal is to see if these dark-adapt…