RETINAL DEGENERATION

This study tests whether the diabetes drug metformin is safe and can slow vision loss in people with ABCA4 retinopathy (Stargardt disease), a genetic condition that causes progressive blindness. About 56 participants aged 12 and older will take metformin daily for 24 months, with…

This study tests two doses of an eye injection called VP-001 in 16 adults with a rare inherited eye disease (PRPF31 mutation) that causes vision loss. The goal is to see if repeated doses are safe and can help slow the disease. Participants must have been in a prior VP-001 study …

This study tests whether dapagliflozin, a drug used for diabetes, can slow the progression of geographic atrophy—an advanced form of dry age-related macular degeneration that causes blind spots. About 70 adults aged 50 and older with non-foveal geographic atrophy will take the dr…

This study tests OpCT-001, a therapy made from special cells that may replace damaged light-sensing cells in the eye. It is for adults with inherited eye diseases like retinitis pigmentosa and Usher syndrome. The goal is to check safety and see if it can improve vision. About 54 …

This study aims to learn how well people with retinal diseases (like retinitis pigmentosa and Stargardt's disease) see in the dark compared to healthy volunteers. Researchers will use special vision tests and eye exams to see if dark adaptation can help detect and track these dis…

This study collects skin, hair, blood, urine, or saliva samples from people with certain eye diseases (like macular degeneration) and from healthy volunteers. Researchers will turn these cells into stem cells in the lab to study how the diseases develop and to test potential new …

This study uses high-resolution and high-speed cameras to take detailed pictures of the eye. The goal is to see tiny structures that regular eye exams miss, which could help doctors better understand diseases like glaucoma, macular degeneration, and diabetes-related eye problems.…