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Stem cell eye treatment could restore sight in retinal disease patients

NCT ID NCT06789445

Recruiting now Disease control Sponsor: BlueRock Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests a new treatment called OpCT-001 for people with inherited eye diseases that damage the retina, such as retinitis pigmentosa. The treatment involves injecting special photoreceptor cells, made from stem cells, into the back of the eye to replace lost cells. The trial will enroll 54 adults and first check safety, then see if it improves vision.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
OpCT-001 (photoreceptor precursor cells made from stem cells)
What this could lead to
If it works, this could slow or reverse vision loss in people with inherited retinal diseases, potentially restoring some sight.
What could go wrong
This is an early, first-in-human trial with only 54 people. The cells may not survive or integrate, and there are risks from surgery and immune reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cone-rod dystrophy inherited retinal dystrophy retinal degeneration retinitis pigmentosa Usher syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CONE-ROD DISEASE CONE-ROD DISEASE (C-RD) CONE-ROD DYSTROPHY INHERITED RETINAL DISEASE (IRD) PRIMARY PHOTORECEPTOR DISEASE RETINAL DEGENERATION RETINITIS PIGMENTOSA (RP) ROD CONE DYSTROPHY ROD-CONE DISEASE USHER SYNDROME

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Mid Atlantic Retina/ Wills Eye

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • Retina Foundation of the Southwest

    RECRUITING

    Dallas, Texas, 75231, United States

    Contact Email: •••••@•••••

  • University of Miami, Bascom Palmer Eye Institute

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Email: •••••@•••••

  • University of Southern California /Children's Hospital of Los Angeles

    RECRUITING

    Los Angeles, California, 90007, United States

    Contact Email: •••••@•••••

  • University of Wisconsin

    RECRUITING

    Madison, Wisconsin, 53705, United States

    Contact Email: •••••@•••••

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