RESPIRATORY TRACT INFECTIONS

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

This study tests whether OM-85 (Broncho-Vaxom), a bacterial extract taken by mouth for 10 days each month, can reduce the number of respiratory infections in children aged 6 months to 5 years who have a history of wheezing. About 525 children will receive either OM-85 or a placeb…

This study is testing two new types of pulse oximeters—simple devices that measure oxygen levels—for babies and toddlers with pneumonia in Cape Town, South Africa. Researchers want to see if these devices help healthcare workers correctly identify children with low oxygen and ref…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This study compares new, less invasive ways to collect samples for respiratory virus testing—like a nasal wash or saliva—against the standard deep nose swab. Researchers want to see if these gentler methods work just as well and cause less pain. About 1,000 adults in the emergenc…

This study follows over 2,000 people and their pets in the Canton of Bern to learn how infections like COVID-19 spread and what social and environmental factors influence transmission. Participants provide samples and answer questionnaires over time. The goal is to improve pandem…

This study follows 2,500 people who visit freshwater beaches in Ontario, Manitoba, and Nova Scotia to see if contact with water containing blue-green algae (cyanobacteria) leads to stomach bugs, respiratory issues, or skin/eye infections. Researchers will also track illness in pe…