RENAL INSUFFICIENCY

This study tested a new method for measuring systolic blood pressure in people with severe kidney failure. Researchers compared a technique that analyzes the pulse wave from the foot to the heart against the standard method of listening with a stethoscope. The goal was to see if …

This study aimed to understand how kidney problems affect the way the body processes a cancer drug called LOXO-292 (selpercatinib). Researchers compared a single dose of the drug in 37 people with varying levels of kidney function to healthy volunteers. The goal was to gather dat…

This study aimed to understand if nerve blocks used for hand or wrist surgery last a different amount of time in people with kidney failure or diabetes compared to healthy people. Researchers enrolled 120 patients having surgery to measure how long the numbing effect lasted. The …

This study aimed to understand how a common antibiotic, ceftriaxone, moves through and is cleared from the bodies of patients with severe, decompensated liver cirrhosis. Researchers observed 20 hospitalized patients who were already receiving this antibiotic and having a procedur…

This study followed up with five adults who have Fabry disease, a rare genetic disorder, to see how they are doing after receiving enzyme replacement therapy (ERT) since childhood—about 15 years total. Researchers checked their kidney and heart function, pain levels, and quality …

This early-stage study tested the safety of an experimental drug called KBP-5074 in healthy volunteers and people with mild to moderate kidney problems. Researchers gave increasing doses to 26 participants to see how their bodies handled the drug and to check for side effects. Th…

This study aimed to understand how kidney problems affect how the body processes an experimental medicine called BI 1015550. It involved 26 adults, some with healthy kidneys and some with moderate or severe kidney impairment. Each participant took a single dose, and researchers m…