RENAL CELL CARCINOMA (RCC)

This study compares two different drug combinations for people with advanced kidney cancer whose first treatment has stopped working. 116 participants will be randomly assigned to receive either vorolanib tablets plus everolimus or the standard drug sunitinib. The goal is to see …

This study tests whether briefly restricting blood flow to an arm one day before kidney cancer surgery helps protect the remaining kidney tissue from injury. Researchers will compare kidney function in 174 patients who either receive this brief 'preconditioning' or proceed direct…

This study is testing a new, more precise radiation technique to treat kidney tumors. The goal is to deliver radiation that destroys the tumor while minimizing damage to the healthy part of the kidney, which could help preserve kidney function. The research will enroll 40 patient…

This study is testing a new targeted radiation drug called 177Lu-TLX250 for people with advanced kidney cancer that has returned or spread after at least two prior treatments. The drug is designed to find and deliver radiation directly to cancer cells. The trial will first find t…

This is the first study in humans testing an experimental drug called CTX-10726 for several advanced cancers that have stopped responding to standard treatments. Researchers will give increasing doses to 70 patients to check safety, determine the best dose, and see if the drug sh…