REM SLEEP BEHAVIOR DISORDER

This study tests an oral drug called PXS-4728A in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition where people act out their dreams. The goal is to see if the drug can reduce brain inflammation (measured by PET scans) and is safe. iRBD often lea…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people who may be in the early stages of Parkinson's disease. Researchers will study 15 adults aged 50-85 with REM sleep behavior disorder, a known risk factor for Parki…

This study uses a special brain scan called DaTSCAN to learn more about diseases like dementia, Parkinson's, and REM sleep behavior disorder. Researchers will compare scan results with clinical diagnoses and other imaging to better understand these conditions. The study involves …

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or similar brain disorders. Researchers will track symptoms like movement, thinking, and smell to design future trials that test treatments to p…

This study looks at whether carvedilol, a drug used for heart failure, can reverse early heart changes seen in people with a sleep disorder that puts them at high risk for Parkinson's disease. Fifteen participants with REM sleep behavior disorder or reduced sense of smell will ta…

This study looks at how the drug carvedilol, typically used for heart conditions, affects brain scans over three years in 15 people who have a high risk of developing Parkinson's disease. Participants have REM sleep behavior disorder and other early signs. The goal is to see if c…