PULPITIS
Clinical trials for PULPITIS explained in plain language.
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New Tooth-Saving technique could replace root canals
Disease control CompletedThis study tested a less invasive treatment called vital pulp therapy against standard root canals for teeth with severe pulp inflammation. In the new approach, dentists removed only the inflamed pulp and placed a natural blood-derived material (PRF) to help the tooth heal. Forty…
Matched conditions: PULPITIS
Phase: NA • Sponsor: Universidad Central de Venezuela • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Could a simple pill replace the drill for toothache emergencies?
Symptom relief CompletedThis study compared an oral steroid (prednisolone) to a partial root canal for relieving severe tooth pain from pulpitis. Only 5 adults with a painful lower molar took part. The goal was to see if the pill could reduce pain enough to delay the full root canal by 72 hours, potenti…
Matched conditions: PULPITIS
Phase: PHASE3 • Sponsor: University Hospital, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Ice and cold saline may ease pain after root canal or pulp treatment
Symptom relief CompletedThis study tested whether applying cryotherapy (ice or cold saline) during dental procedures for deep cavities reduces pain and improves quality of life. 144 adults received either a pulpotomy or root canal treatment, with or without cryotherapy. The goal was to see if the cold t…
Matched conditions: PULPITIS
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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AI helps dentists spot hidden infections – could save more teeth from root canals?
Symptom relief CompletedThis study tested a procedure called full pulpotomy (removing only the infected pulp inside the tooth crown) in 58 adults with severe toothache. It compared success in teeth with and without an infection at the root tip (apical periodontitis), using an AI tool to help detect the …
Matched conditions: PULPITIS
Phase: NA • Sponsor: Misr International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Light therapy may ease root canal pain
Symptom relief CompletedThis study tested whether photodynamic therapy (PDT) — a light-activated disinfection method — can reduce pain after root canal treatment. 95 adults with infected back teeth received either standard cleaning or PDT-enhanced cleaning. Researchers measured pain levels and painkille…
Matched conditions: PULPITIS
Sponsor: Atlas University • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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AI predicts dental numbing success in painful tooth condition
Knowledge-focused CompletedThis study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…
Matched conditions: PULPITIS
Sponsor: Jamia Millia Islamia • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Scientists probe the chemistry of tooth pain and stress
Knowledge-focused CompletedThis completed study looked at 72 adults to see how certain chemicals (Substance P and CGRP) in saliva and tooth pulp relate to dental pain, inflammation, and stress. Participants provided saliva samples and had pulp tissue collected during routine root canal treatment. The goal …
Matched conditions: PULPITIS
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Tooth inflammation biomarkers measured in new study
Knowledge-focused CompletedThis study looked at 51 people to compare levels of three substances (IL-8, FGF-1, and VEGF) in teeth that are healthy, mildly inflamed, or severely inflamed. Samples were taken from the tooth pulp, gum fluid, and dentin fluid during routine root canal treatment. The goal was to …
Matched conditions: PULPITIS
Sponsor: Kırıkkale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC