PLASMA CELL MYELOMA

This study tested whether adding the drug isatuximab to a standard two-drug regimen (carfilzomib and dexamethasone) helps people with multiple myeloma that has come back or stopped responding to prior treatments. 302 adults who had already received 1 to 3 prior therapies took par…

This study tested whether giving two drugs (ixazomib and lenalidomide) in an alternating schedule after a stem cell transplant could safely help keep multiple myeloma from coming back. Thirty patients who had already received a transplant took part. The main goal was to check for…

This early-stage study tested a new drug called SAR442085 in 37 adults with multiple myeloma that had returned or stopped responding to prior treatments. The main goals were to find a safe dose and check for early signs that the drug can shrink or control the cancer. The study is…

This study looked at 77 people with multiple myeloma or non-Hodgkin lymphoma who had a stem cell transplant. Half got a drug called tbo-filgrastim (a growth factor) after transplant, and half did not. The goal was to see if skipping the drug still allowed patients to leave the ho…

This study looked at 42 people with multiple myeloma that remained after a stem cell transplant. It compared taking lenalidomide alone versus adding two other drugs (ixazomib and dexamethasone) to see if the combo could better clear the leftover cancer. The goal was to find a mor…

This study tested a two-step stem cell transplant for 62 people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor immune cells followed by a stem cell transplant. The goa…

This study tested a drug called daratumumab in 49 patients with multiple myeloma who were eligible for a stem cell transplant. The goal was to see if daratumumab could help eliminate remaining cancer cells in the bone marrow after transplant. While the treatment aims to control t…

This study tested whether using a battery-powered drill for bone marrow biopsy causes less pain and provides better tissue samples than the traditional manual needle method. 100 adults with plasma cell disorders (like multiple myeloma) took part. The goal was to see if the drill …

This study looked at whether giving the multiple myeloma drug Darzalex Faspro at home is practical and satisfying for patients. Twenty adults with multiple myeloma who were already on a monthly daratumumab regimen received their injections at home. The main goal was to measure tr…

This study looked at 56 older adults (65+) with multiple myeloma to see if a comprehensive geriatric assessment—a series of questions and tests about physical and mental health—along with blood tests could predict who would have more side effects from chemotherapy. The goal is to…

This study tested a personalized geriatric optimization plan (GO!) in 30 patients aged 60 and older who were getting a stem cell transplant for blood cancers or bone marrow failure. The plan included tailored changes to diet, sleep, activity, and medications. The goal was to see …