PARKINSON'S DISEASE AND PARKINSONISM

This study tests whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers look for a protein called alpha-synuclein in the colon of people already diagnosed with Parkinson's. If successful, this could lead to earlier detection a…

This study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…

This study tests a new exercise method for people with Parkinson's disease. Researchers will see if partially restricting blood flow to the legs during balance-challenging strength exercises can improve symptoms. The study involves 20 participants aged 40 to 85 and focuses on whe…

This study tests whether a mild electrical brain stimulation technique called tDCS can improve swallowing difficulties in people with Parkinson's disease. 58 participants will receive either real or sham tDCS alongside standard swallowing therapy. Researchers will measure changes…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study compares two different deep brain stimulation (DBS) settings in 30 people with Parkinson's disease who already have DBS implants. The goal is to see which setting better improves walking and balance problems. Participants will try both settings, and their symptoms will…

This study looks at how deep brain stimulation (DBS) — a device already used to control movement in Parkinson's disease — affects sleep. Researchers will monitor brain activity and sleep quality in 64 adults with Parkinson's who have or will get DBS implants. The goal is to under…