PARKINSON'S DISEASE (PD)

This study tests an experimental oral drug called EC5026 in 18 adults with Parkinson's disease. The main goal is to see if the drug is safe and how it works in the body, but researchers will also check if it helps improve symptoms. Participants take the drug or a placebo daily fo…

This study tests whether a personalized, non-invasive brain stimulation method called rTMS, combined with walking exercises, is tolerable and shows early promise for reducing freezing of gait in people with Parkinson's disease. Up to 15 adults aged 50-80 will receive the treatmen…

This study is testing whether a non-invasive technique called transcranial ultrasound stimulation (TUS) can safely improve thinking, movement, and quality of life in people with neurodegenerative diseases like Parkinson's and Alzheimer's. Twenty adults aged 18-80 with these condi…

This study tests a special shoe called NUSHU that has sensors to measure walking and balance in people with early to advanced Parkinson's disease and in healthy volunteers. The shoe can also give gentle vibrations to help with walking problems. Researchers want to see if the shoe…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, can weaken the immune system over time. Researchers will measure immune cells and antibodies in 24 patients before and after 6 months and 1 year of treatment. The goal is to understand i…

This study looks at how deep brain stimulation (DBS) changes the way people with Parkinson's disease, essential tremor, or dystonia pay attention and perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, d…

This study tests a new interface that synchronizes two types of brain stimulation—transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS)—in people with Parkinson's disease. The goal is to see if the interface can precisely time the stimulation pulses…