PALB2 GENE MUTATION
Clinical trials for PALB2 GENE MUTATION explained in plain language.
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New drug combo targets tough prostate cancer in understudied groups
Disease control TerminatedThis study tested a combination of two drugs (niraparib and abiraterone plus prednisone) for men with metastatic hormone-sensitive prostate cancer that has certain gene mutations. It focused on Hispanic/Latino and Black patients, who are often underrepresented in research. The go…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: Qian Qin • Aim: Disease control
Last updated May 14, 2026 12:06 UTC
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New hope: targeted drug olaparib shows promise for Hard-to-Treat breast cancers
Disease control OngoingThis study tests a drug called olaparib in people with metastatic breast cancer that has spread beyond the breast. Participants must have a specific gene mutation that makes their cancer cells less able to repair DNA damage. The goal is to see if olaparib can shrink tumors or slo…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Disease control
Last updated May 11, 2026 20:53 UTC
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New hope for tough cancers: drug targets BRCA mutations
Disease control OngoingThis study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…
Matched conditions: PALB2 GENE MUTATION
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 01, 2026 15:59 UTC
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Genetic counseling by phone may ease cancer fears in High-Risk women
Knowledge-focused TerminatedThis study looks at whether watching an online genetics video, with or without phone counseling, helps reduce stress about cancer risk in women with triple-negative breast cancer. About 5,200 women aged 30 or older who have at least one ovary and a history of early or triple-nega…
Matched conditions: PALB2 GENE MUTATION
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated May 15, 2026 11:53 UTC
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New database aims to intercept deadly pancreatic cancer before it's too late
Knowledge-focused OngoingThis study is creating a large database of people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. The goal is to track their health over time to find better ways to detect and prevent the disease early. About 317 participa…
Matched conditions: PALB2 GENE MUTATION
Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Knowledge-focused
Last updated May 11, 2026 20:49 UTC